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REVIEW article
Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1429858
Unveiling the Role of Long Non-coding RNA MALAT1: A Comprehensive Review on Myocardial Infarction
Provisionally accepted- 1 Kashan University of Medical Sciences, Kashan, Isfahan, Iran
- 2 yazd university of medical sciences, yazd, Iran
- 3 Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran
Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult. The function of lncRNAs extends to regulating gene expression in various conditions, both physiological and pathological, such as cardiovascular diseases. The objective of this research is to extensively evaluate the significance of the lncRNA called Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in the development and management of MI. According to research, MALAT1 is implicated in processes such as autophagy, apoptosis, cell proliferation, and inflammation in the cardiovascular system. This investigation examines recent research examining the effects of MALAT1 on heart function and its potential as a mean of diagnosis and treatment for post-MI complications and ischemic reperfusion injury.
Keywords: Myocardial Infarction, long non-coding RNA, Metastasis associated lung adenocarcinoma transcript 1, epigenetic, Pathology
Received: 11 May 2024; Accepted: 15 Jul 2024.
Copyright: © 2024 Eshraghi, Sadati, Bahrami, Mirjalili, Farrokhian, Mahjoubin-Tehran and Mirzaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hamed Mirzaei, Kashan University of Medical Sciences, Kashan, 8713781147, Isfahan, Iran
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