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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Hypertension
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1429112
This article is part of the Research Topic The Newer Paradigms in Hypertension Research and Management View all 9 articles

Impact of high hemoglobin levels on carotid artery intima-media thickness and its predictive value for hypertension in high-altitude areas: a real-world study

Provisionally accepted
hongyu long hongyu long 1*ga long ga long 2*yiqian zhang yiqian zhang 1*qiuyu xu qiuyu xu 3*Kemin LI Kemin LI 4Maiyongcuo Qing Maiyongcuo Qing 2*ming xiong ming xiong 1*
  • 1 Chengdu First People’s Hospita, Chengdu, Sichuan Province, China
  • 2 Dege County People's Hospital, Dege, China
  • 3 The Second People's Hospital of Jiangyang District, Sichuan, China
  • 4 West China Second University Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    The hemoglobin levels in the peripheral blood of individuals living at high altitudes are significantly higher than normal levels. These levels are closely associated with atherosclerosis and cardiovascular events. This study aimed to investigate the correlation between hemoglobin levels in the peripheral blood and hypertension in high-altitude regions, providing a basis for preventing and treating primary hypertension in these regions.Materials and Methods: From May 2020 to May 2021, patients diagnosed with primary hypertension in plateau regions of China were selected as participants. The clinical data, including lifestyle habits and blood biochemical indicators, were collected from the clinical case database for patients meeting the inclusion criteria. The logistic regression analysis was performed to identify factors influencing carotid intima-media thickness in patients with primary hypertension in plateau regions. The ROC curve was plotted to analyze the impact of peripheral blood hemoglobin levels on hypertension, determine the hemoglobin threshold for predicting hypertension in plateau areas, and evaluate the predictive value of hemoglobin level for hypertension.Results: A total of 200 patients (105 men with an average age of 64.8 ± 12.75 years and 95 women with an average age of 69.5 ± 11.54 years) were enrolled in this study. Logistic regression analysis revealed that age, CO2-CP, ALT, APOB, CRP, and HGB were independent risk factors for increased carotid artery intima-media thickness (P < 0.05). The hemoglobin threshold for predicting hypertension in high-altitude areas was 131 g/L. The area under the ROC curve for predicting hypertension with elevated hemoglobin level was 0.799 (0.719-0.880).Conclusion: Elevated hemoglobin levels contribute to the thickening of the carotid artery intima-media layer and hold predictive value for high-altitude hypertension.

    Keywords: Carotid Intima-Media Thickness, Hemoglobin, Hypertension, Plateau region, Predictive Value, Real-world study

    Received: 07 May 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 long, long, zhang, xu, LI, Qing and xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    hongyu long, Chengdu First People’s Hospita, Chengdu, Sichuan Province, China
    ga long, Dege County People's Hospital, Dege, China
    yiqian zhang, Chengdu First People’s Hospita, Chengdu, Sichuan Province, China
    qiuyu xu, The Second People's Hospital of Jiangyang District, Sichuan, China
    Maiyongcuo Qing, Dege County People's Hospital, Dege, China
    ming xiong, Chengdu First People’s Hospita, Chengdu, Sichuan Province, China

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