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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1427653

Improving Long-Term Postoperative Survival in a Porcine Cardiac Valve Surgery Model Utilizing Cardiopulmonary Bypass via Left Thoracotomy: A Single-Center Experience Sharing Insights

Provisionally accepted
Xia Qingping Xia Qingping 1Yong Cao Yong Cao 1Jialuan Li Jialuan Li 2Jie Jiang Jie Jiang 2Xuan lu Xuan lu 2Li Deng Li Deng 1*
  • 1 The People’s Hospital of Gaozhou, Gaozhou, China
  • 2 Other, Guangzhou, China

The final, formatted version of the article will be published soon.

    The objective of this study was to improve long-term postoperative survival in a porcine cardiac valve surgery model by utilizing cardiopulmonary bypass (CPB) via left thoracotomy. The study aimed to share refined techniques and insights accumulated over years at a single-center animal clinical trial facility.A total of 196 Chinese Large White pigs weighing between 60 and 75 kg were used in the study. All animals underwent cardiac valve surgeries via left thoracotomy with CPB. Surgical techniques included mitral valve replacement, mitral valve repair, aortic valve replacement, OZAKI procedure, ascending aorta replacement, and left ventricular assist device implantation. Anesthesia and CPB protocols were optimized to minimize stress and complications. Postoperative care was standardized to enhance recovery and survival.All 196 pigs survived the surgical procedures, with no deaths reported. The mean surgical duration was 168.55 ± 38.75 minutes, CPB time was 114.89 ± 32.11 minutes, and aortic cross-clamp time was 76.75 ± 21.33 minutes. Automatic heart resumption occurred in 63.8% of pigs, while the remainder required electrical defibrillation or cardiac massage.The postoperative mechanical ventilation time was 2.44 ± 0.58 minutes, and the average drainage volume at 2 hours postoperatively was 27.50 ± 9.70 mL. There were no cases of 3 postoperative hemorrhage complications or blood transfusions, and surgical site infections occurred in only 1.5% of pigs.The surgical approach utilizing left thoracotomy with CPB has proven effective in significantly enhancing long-term survival rates in porcine heart surgeries. The refined techniques and standardized operational procedures described in this study offer valuable insights for researchers aiming to improve the success of porcine heart valve surgical models. However, due to differences in animal anatomy, the applicability of this surgical approach to other animal models still requires further exploration.

    Keywords: Porcine Cardiac Valve Surgery, Cardiopulmonary Bypass, Left thoracotomy, Postoperative survival, follow -up

    Received: 04 May 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Qingping, Cao, Li, Jiang, lu and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Deng, The People’s Hospital of Gaozhou, Gaozhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.