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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Hypertension
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1426953
This article is part of the Research Topic The Newer Paradigms in Hypertension Research and Management View all 7 articles

The relationship between the age of onset of hypertension and chronic kidney disease: A cross-sectional study of the American population

Provisionally accepted
Lanlan Qiu Lanlan Qiu 1Bo Wu Bo Wu 2*
  • 1 Longyan People's Hospital, Longyan, Fujian Province, China
  • 2 Department of Cardiology;Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China

The final, formatted version of the article will be published soon.

    Background: Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD. Objective: We investigated the relationship between the age of onset of hypertension and CKD. Method: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension (n = 19,516); Group 2, age of onset < 35 years (n = 2,180); Group 3, 35 ≤ age of onset < 45 years (n = 2,128); and Group 4, age of onset ≥ 45 years (n = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD.Results: After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53-4.14, P < 0.001; Group 3 OR: 1.59, 95% CI: 1.01-2.51, P = 0.048; Group 4 OR: 1.54, 95% CI: 1.00-2.38, P = 0.050).There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.

    Keywords: Hypertension, Onset age, early-onset hypertension, CKD, NHANES

    Received: 02 May 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Qiu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bo Wu, Department of Cardiology;Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China

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