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SYSTEMATIC REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1421013
This article is part of the Research Topic Advances in Multi-Modality Imaging for Precision Medicine in Cardiomyopathies View all articles

Cardiac magnetic resonance imaging for discrimination of hypertensive heart disease and hypertrophic cardiomyopathy: a systematic review and meta-analysis

Provisionally accepted
Qingyuan Zhao Qingyuan Zhao 1Zhiyu Chen Zhiyu Chen 1*Chengcheng Qi Chengcheng Qi 1*Sunan Xu Sunan Xu 1*Ruichen Ren Ruichen Ren 1Wenting Li Wenting Li 1Xiaoxue Zhang Xiaoxue Zhang 2*Yang Zhang Yang Zhang 1*
  • 1 radiology, Qilu Hospital, Shandong University, Jinan, China
  • 2 Shandong University, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Introduction: Differentiating hypertensive heart disease (HHD) from hypertrophic cardiomyopathy (HCM) is crucial yet challenging due to overlapping clinical and morphological features. Recent studies have explored the use of various cardiac magnetic resonance (CMR) parameters to distinguish between these conditions, but findings have remained inconclusive. This study aims to identify which CMR parameters effectively discriminate between HHD and HCM and to investigate their underlying pathophysiological mechanisms through a meta-analysis.The researchers conducted a systematic and comprehensive search for all studies that used CMR to discriminate between HHD and HCM and calculated the Hedges'g effect size for each of the included studies, which were then pooled using a random-effects model and tested for the effects of potential influencing variables through subgroup and regression analyses.Results: In this review, 26 studies encompassing 1349 HHD and 1581 HCM cases were included for meta-analysis. Analysis revealed that HHD showed a significant lower in T1 mapping (g = -0.469, P < 0.001), extracellular volume (g = -0.417, P = 0.024), left ventricular mass index (g = -0.437, P < 0.001), and maximal left ventricular wall thickness (g = -2.076, P < 0.001), alongside a significant higher in end-systolic volume index (g = 0.993, P < 0.001) and end-diastolic volume index (g = 0.553, P < 0.001), compared to HCM.This study clearly demonstrates that CMR parameters can effectively differentiate between HHD and HCM. HHD is characterized by significantly lower diffuse interstitial fibrosis and myocardial hypertrophy, along with better-preserved diastolic function but lower systolic function, compared to HCM. The findings highlight the need for standardized CMR protocols, considering the significant influence of MRI machine vendors, post-processing software, and study regions on diagnostic parameters. These insights are crucial for improving diagnostic accuracy and optimizing treatment strategies for patients with HHD and HCM.

    Keywords: Hypertensive heart disease, Hypertrophic Cardiomyopathy, cardiac magnetic resonance imaging, T1 Mapping, ECV, Strain

    Received: 21 Apr 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Zhao, Chen, Qi, Xu, Ren, Li, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhiyu Chen, radiology, Qilu Hospital, Shandong University, Jinan, China
    Chengcheng Qi, radiology, Qilu Hospital, Shandong University, Jinan, China
    Sunan Xu, radiology, Qilu Hospital, Shandong University, Jinan, China
    Xiaoxue Zhang, Shandong University, Jinan, 250100, Shandong Province, China
    Yang Zhang, radiology, Qilu Hospital, Shandong University, Jinan, China

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