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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1419466

Causal association between common rheumatic diseases and arrhythmia: a Mendelian randomization study

Provisionally accepted
Yuchen Zhang Yuchen Zhang ke zhang ke zhang ling tang ling tang xinai meng xinai meng tian liu tian liu Yanjia Chen Yanjia Chen Xingfu Huang Xingfu Huang *
  • Southern Medical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Observational studies have suggested a link between rheumatic diseases and arrhythmias. However, these studies have been limited by confounding factors and reverse causality, leaving the causal relationship between rheumatic diseases and arrhythmias uncertain. This study addresses this inquiry using genetic evidence.Methods: Selected single nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS) data were employed as instrumental variables. Inverse variance weighting (IVW), MR-Egger regression, and the weighted median method were utilized in the two-sample Mendelian randomization analysis. Horizontal pleiotropy was identified and rectified through the MR-PRESSO test and MR-Egger regression. The stability and reliability of the Mendelian randomization results were appraised using the remain-one method, Cochran Q test, and funnel plot. Odds ratios (OR) were utilized to assess the causal relationship between six rheumatic diseases and five types of arrhythmias.The Inverse Variance Weighted (IVW) method indicated a significant association between rheumatoid arthritis (RA) and an elevated risk of right bundle branch block (RBBB) (OR: 1.10, 95% CI: 1.02 to 1.18, p = 0.009). Additionally, gout was significantly correlated with an augmented risk of RBBB (OR: 1.28, 95% CI: 1.09 -1.51, p = 0.003). Conversely, dermatomyositis (DM) exhibited a negative association with the risk of atrioventricular block (AVB) (OR: 0.94, 95% CI: 0.90 to 0.99, p = 0.020). No significant associations were observed between other rheumatic diseases and arrhythmias.A two-sample Mendelian Randomization (MR) study provides data indicating that in European populations, a genetically predicted gout or rheumatoid arthritis (RA) may increase the

    Keywords: Mendelian randomization, arrhythmia, Rheumatic Diseases, single-nucleotide polymorphisms, RBBB

    Received: 18 Apr 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Zhang, zhang, tang, meng, liu, Chen and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xingfu Huang, Southern Medical University, Guangzhou, China

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