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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1418781
This article is part of the Research Topic The Role of Sex in Coronary Artery Disease: Volume II View all articles

Prognostic value of the derived inflammatory marker SIRI in postmenopausal women with coronary artery disease

Provisionally accepted
Pengli Yang Pengli Yang Rui Xue Rui Xue Yuhang Wei Yuhang Wei Chenxi Cao Chenxi Cao Songcheng Yu Songcheng Yu Shanling Peng Shanling Peng Wenjing Zhang Wenjing Zhang Yunzhe Wang Yunzhe Wang Ying-Ying Zheng Ying-Ying Zheng Gangqiong Liu Gangqiong Liu *
  • First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Objective: The aim of this study was to explore the predictive value of the Systemic Inflammatory Response Index (SIRI) for the prognosis of older postmenopausal women with coronary artery disease (CAD).This retrospective cohort study included 617 postmenopausal female patients aged 50 years or older with a CAD diagnosis confirmed by coronary angiography seen at the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020.Patients were divided into three groups based on SIRI tertiles. Primary endpoints were all-cause mortality (ACM) and cardiac mortality (CM), and secondary endpoints were major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).The frequencies of all adverse outcomes were greater in the high level (third tertile) SIRI group than in the low level (first tertile) SIRI group. Multivariable regression analysis showed that compared to the low level SIRI group, the high level SIRI group had a 1.581-fold greater risk of ACM [hazard ratio (HR)= 2.581, 95% confidence interval (CI): 1.045-6.373, p=0.040) and a 1.798-fold greater risk of CM (HR=2.798, 95% CI: 0.972-8.060, p=0.057). In addition, the risks of MACEs and MACCEs were 62.3% (HR=1.623, 95% CI: 1.123-2.346, p=0.01) and 55.8% (HR=1.558, 95% CI: 1.100-2.207, p=0.012) greater in the high level SIRI group compared with the low level SIRI group. Kaplan-Meier survival analyses confirmed that the high SIRI level was 4 associated with increased risks of ACM (p=0.001), CM (p=0.005), MACEs (p=0.003), and MACCEs (p=0.005).This retrospective study demonstrates that the novel derived inflammatory index SIRI can effectively predict the risk of multiple adverse outcomes in postmenopausal women with CAD.

    Keywords: systemic inflammatory response index, postmenopausal women, Coronary Artery Disease, Adverse prognosis, derived inflammatory marker

    Received: 17 Apr 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Yang, Xue, Wei, Cao, Yu, Peng, Zhang, Wang, Zheng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gangqiong Liu, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

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