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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Pediatric Cardiology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1414089

Transcriptomics integrated with metabolomics reveals partial molecular mechanisms of nutritional risk and neurodevelopment in children with congenital heart disease

Provisionally accepted
Minglei Gao Minglei Gao 1Yang Shen Yang Shen 2Ping Yang Ping Yang 2Chang Yuan Chang Yuan 2Yanan Sun Yanan Sun 2Zipu Li Zipu Li 1*
  • 1 Qingdao Women and Children's Hospital, Qingdao, China
  • 2 Dalian Women and Children’s Medical Center(Group), Dalian, Liaoning Province, China

The final, formatted version of the article will be published soon.

    To explore molecular mechanisms affecting nutritional risk and neurodevelopment in children with congenital heart disease (CHD) by combining transcriptome and metabolome analysis. A total of 26 blood and serum samples from 3 groups of children with CHD low nutritional risk combined with normal neurodevelopment (group A), low nutritional risk combined with neurodevelopmental disorders (group B) and high nutritional risk combined with normal neurodevelopment (group C)) were analyzed by transcriptome and metabolomics to search for differentially expressed genes (DEGs) and metabolites (DEMs). Functional analysis was conducted for DEGs and DEMs. Further, the joint pathway analysis and correlation analysis of DEGs and DEMs were performed. A total of 362 and 1351 DEGs were detected in group B and C compared to A, respectively. A total of 6 and 7 DEMs were detected in group B and C compared to A in positive mode, respectively. There were 39 and 31 DEMs in group B and C compared to A in negative mode. Transcriptomic analysis indicated that neurodevelopment may be regulated by some genes such as NSUN7, SLC6A8, CXCL1 and LCN8,

    Keywords: congenital heart disease, Nutritional risk, neurodevelopment, Transcriptomics, Metabolomics

    Received: 08 Apr 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Gao, Shen, Yang, Yuan, Sun and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zipu Li, Qingdao Women and Children's Hospital, Qingdao, China

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