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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1413984

Association between Mitral Annulus Calcification (MAC) and Severity of Coronary Artery Disease Assessed by SYNTAX Score in Patients Presented with Acute Coronary Syndrome

Provisionally accepted
Afsaneh Esmailpour Afsaneh Esmailpour 1Soroush Nematollahi Soroush Nematollahi 1Reza Hali Reza Hali 1*Mohammad Sadeghian Mohammad Sadeghian 1Sepehr Nayebirad Sepehr Nayebirad 1Ahmad Vakili Ahmad Vakili 1,2
  • 1 Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  • 2 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Alborz, Iran

The final, formatted version of the article will be published soon.

    Objectives: Mitral annulus calcification (MAC) has been linked to cardiovascular disease severity, but its relationship with the SYNTAX score (SS) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the association between MAC and SS in ACS patients to explore the role of MAC in predicting cardiovascular disease severity. Methods: We conducted a cross-sectional study of 233 ACS patients at Tehran Heart Center, Tehran, Iran, from December 2021 to August 2022. Patients with prior coronary artery disease (CAD) were excluded. Demographic data, risk factors, and medical history were extracted from clinical files. SS was determined using coronary angiography, and MAC was assessed via two-dimensional transthoracic echocardiography. Results: The study population had a mean age of 58.79 years, with 74.7% male. MAC was present in 24.9% of participants, and 57% of those with MAC had an SS above 23. Univariate analysis revealed a significant association between MAC and higher SSs (odds ratio: 1.84, 95% CI: 1.02-3.39; P=0.046). However, multivariable analysis showed that only left ventricular ejection fraction (LVEF) was independently associated with SS (odds ratio: 0.94, 95% CI: 0.89-0.99; P=0.015). Conclusion: While MAC was initially associated with higher SSs in ACS patients, only LVEF emerged as an independent predictor in the multivariable analysis. Although MAC may not be independently associated with SS, it may serve as a useful echocardiographic indicator of more severe CAD in ACS.

    Keywords: Mitral annulus calcification, Syntax score, Coronary Artery Disease, Acute Coronary Syndrome, Angiography

    Received: 08 Apr 2024; Accepted: 04 Oct 2024.

    Copyright: © 2024 Esmailpour, Nematollahi, Hali, Sadeghian, Nayebirad and Vakili. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Reza Hali, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

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