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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1412195
This article is part of the Research Topic Insights in Cardiac Rhythmology: 2023 View all 10 articles

Cardioneuroablation: the known and the unknown

Provisionally accepted
Aldo Marrese Aldo Marrese Riccardo Persico Riccardo Persico Emanuele Parlato Emanuele Parlato Daniele Faccenda Daniele Faccenda Alfonsomaria Salucci Alfonsomaria Salucci Gianluigi Comparone Gianluigi Comparone Valerio Pergola Valerio Pergola Lucio Addeo Lucio Addeo Celeste Fonderico Celeste Fonderico Luigi Cocchiara Luigi Cocchiara Alessandro Volpe Alessandro Volpe Pasquale Visconti Pasquale Visconti Giuseppe Ammirati Giuseppe Ammirati Antonio Rapacciuolo Antonio Rapacciuolo Teresa Strisciuglio Teresa Strisciuglio *
  • University of Naples Federico II, Naples, Italy

The final, formatted version of the article will be published soon.

    Cardioneuroablation (CNA) is a novel interventional procedure for the treatment of recurrent vasovagal syncope (VVS) and advanced atrioventricular block secondary to hyperactivation of vagal tone in young patients. By damaging the cardiac parasympathetic ganglia, CNA seems to be able to mitigate and/or abolish the excessive vagal activity and improve patients' outcome. This review is intended to give a detailed and comprehensive overview of the current evidences regarding 1) the clinical applications of CNA 2) the identification of ablation targets and procedural endpoints 3) the medium-long term effect of the procedure and its future perspectives. However, clinical data are still limited, and expert consensus or recommendations in the guidelines regarding this technique are still lacking.

    Keywords: Cardioneuroablation (CNA), vasovagal syncope, Atrioventicular block, High-frequency stimulation (HFS), fractionated electrograms, Cardioinhibitory syncope

    Received: 04 Apr 2024; Accepted: 28 Jun 2024.

    Copyright: © 2024 Marrese, Persico, Parlato, Faccenda, Salucci, Comparone, Pergola, Addeo, Fonderico, Cocchiara, Volpe, Visconti, Ammirati, Rapacciuolo and Strisciuglio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Teresa Strisciuglio, University of Naples Federico II, Naples, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.