Ke-yun Cheng
Tian Lan
Zhu-Jun Mao
Youyao Xu
Wei Lu
Qing Shen
Xi-xi Zeng
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1411621
CircRNA-Mediated Regulation of Cardiovascular Disease
Provisionally accepted- Quzhou City People's Hospital, Quzhou, China
Cardiovascular diseases (CVDs) encompass a range of disorders affecting the heart and blood vessels, such as coronary heart disease, cerebrovascular disease (e.g., stroke), peripheral arterial disease, congenital heart anomalies, deep vein thrombosis, and pulmonary embolism. CVDs are often referred to as the leading cause of mortality worldwide. Recent advancements in deep sequencing have unveiled a plethora of noncoding RNA transcripts, including circular RNAs (circRNAs), which play pivotal roles in the regulation of CVDs. A decade of research has differentiated various circRNAs by their vasculoprotective or deleterious functions, revealing potential therapeutic targets. This review provides an overview of circRNAs and a comprehensive examination of CVDs, the regulatory circRNAs within the vasculature, and the burgeoning research domain dedicated to these noncoding RNAs.
Keywords: Cardiovascular Diseases, risk, CircRNA Abbreviations: ADSCs, adipose-derived mesenchymal stem cells, AF, atrial fibrillation, AHA, American Heart Association, AMI, Acute Myocardial Infarction, ASCVD, atherosclerotic cardiovascular disease, CAD, coronary artery disease
Received: 19 Apr 2024; Accepted: 08 Nov 2024.
Copyright: © 2024 Cheng, Wang, Lan, Mao, Xu, Lu, Tong, Shen and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xi-xi Zeng, Quzhou City People's Hospital, Quzhou, China
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