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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1409605
Identification of Iron Metabolism-Related Genes in Coronary Heart Disease and Construction of a Diagnostic Model
Provisionally accepted- Department of Traditional Chinese Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, China
Background: Coronary heart disease is a common cardiovascular disease, yferroptosiset its relationship with iron metabolism remains unclear.Methods: Gene expression data from peripheral blood samples of patients with coronary heart disease and a healthy control group were utilized for a comprehensive analysis that included differential expression analysis, weighted gene coexpression network analysis, gene enrichment analysis, and the development of a logistic regression model to investigate the associations and differences between the groups. Additionally, the CIBERSORT algorithm was employed to examine the composition of immune cell types within the samples.Results: Eight central genes were identified as being both differentially expressed and related to iron metabolism. These central genes are mainly involved in the cellular stress response. A logistic regression model based on the central genes achieved an AUC of 0.64-0.65 in the diagnosis of coronary heart disease. A higher proportion of M0 macrophages was found in patients with coronary heart disease, while a higher proportion of CD8 T cells was observed in the normal control group.The study identified important genes related to iron metabolism in the pathogenesis of coronary heart disease and constructed a robust diagnostic model. The results suggest that iron metabolism and immune cells may play a significant role in the development of coronary heart disease, providing a basis for further research.
Keywords: coronary heart disease, iron metabolism, Diagnostic model, Immune infiltration, WGCNA
Received: 30 Mar 2024; Accepted: 31 Oct 2024.
Copyright: © 2024 zhu, Zhang, Fan, Su and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhi Jin, Department of Traditional Chinese Medicine, The Second Hospital of Shandong University, Jinan, 250012, Shandong Province, China
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