AUTHOR=Guo Yadi , Luo Dongling , Yin Li , Su Xiaoyan , Yuan Zhimin , Huang Hui , Chen Jie 

TITLE=Varying association of nutrient intakes with quality of life in patients receiving different modes of dialysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1407650

DOI=10.3389/fcvm.2024.1407650

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Nutrients are crucial for dialysis patients, especially elderly patients. Nutrition-related complications in dialysis patients are often closely related to cardiovascular aging. However, we know little about the effect of different nutrients on the commonly used outcome predictor, health-related quality of life (HRQOL). Therefore, this study investigated the associations between different nutrients and HRQOL among dialysis patients.</p></sec><sec><title>Methods</title><p>A cross-sectional study was conducted on 123 dialysis adults at multiple dialysis centers. The Short Form-36 Health Survey (SF-36) assesses HRQOL. Modified quantitative subjective global assessment (MQSGA) evaluates nutritional status. A 3-day dietary record evaluated nutrient intakes.</p></sec><sec><title>Results</title><p>Among the 123 participants, 79 received hemodialysis (HD), and 44 were on peritoneal dialysis (PD). Patients with PD had a higher SF-36 score than HD (525 ± 136 vs. 375 ± 179, <italic>P</italic> &lt; 0.001). A negative association between nutrition status and HRQOL was observed in HD (regression coefficient <italic>β</italic> = −17.4, <italic>P</italic> &lt; 0.001) but not in PD (<italic>β</italic> = −12.3, <italic>P</italic> = 0.07). For HD patients, the nutrition status was negatively correlated with intakes of carbohydrates, fiber, selenium, copper, and Manganese (<italic>β</italic> = −0.02, <italic>P</italic> = 0.032; <italic>β</italic> = −0.3, <italic>P</italic> = 0.031; <italic>β</italic> = −0.1, <italic>P</italic> = 0.006; <italic>β</italic> = −2.3, <italic>P</italic> = 0.025; <italic>β</italic> = −1.3, <italic>P</italic> = 0.003, respectively). Their HRQOL was positively associated with calories, fat, niacin, and vitamin E (<italic>β</italic> = 2.19, <italic>P</italic> = 0.035; <italic>β</italic> = 2.4, <italic>P</italic> = 0.043; <italic>β</italic> = 8.5, <italic>P</italic> = 0.044; <italic>β</italic> = 6.9, <italic>P</italic> = 0.017, respectively). Conversely, for patients with PD, only vitamin B2 was found to be adversely correlated with their nutritional status (<italic>β</italic> = −5.2, <italic>P</italic> = 0.037), and increased intakes of vitamin A, vitamin C and fiber (<italic>β</italic> = 0.1, <italic>P</italic> = 0.031; <italic>β</italic> = 0.8, <italic>P</italic> = 0.028; <italic>β</italic> = 15.8, <italic>P</italic> = 0.045, respectively) were associated with a better HRQOL.</p></sec><sec><title>Conclusions</title><p>The nutritional intake of PD patients and HD patients affects their quality of life differently. Macronutrients significantly impact HRQOL in HD patients, while vitamins have a more substantial impact on PD patients.</p></sec>