Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Heart Valve Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1404284

Causal relationship between immunophenotypes and mitral valve prolapse: a bidirectional Mendelian randomization study

Provisionally accepted
Yue Wang Yue Wang 1Yusi Shen Yusi Shen 2Lina Tan Lina Tan 1Liangbo Hu Liangbo Hu 1Min He Min He 1Xiaocong Zeng Xiaocong Zeng 1*
  • 1 Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
  • 2 Department of Orthopedic Rehabilitation, Taihe Hospital, Hubei University of Medicine, Shiyan, China

The final, formatted version of the article will be published soon.

    Emerging evidence indicates a significant link between various immune cell types and the development of heart valve disorders. Mitral valve prolapse (MVP) is a common condition that can lead to heart failure, arrhythmias, and even sudden death. Currently, the role of immune cells in MVP is not well understood. Thus, this study aimed to explore the causal relationship between immunophenotypes and the risk of MVP.This study conducted a two-sample Mendelian randomization (MR) analysis to examine the link between 731 immunophenotypes and MVP. Publicly available data from genome-wide association studies were used for both the exposures and outcomes.The primary method for assessing the causal relationship between mitral valve prolapse and the 731 immunophenotypes was the inverse variance weighted method.Additionally, to ensure the MR results were reliable and valid, sensitivity analyses, 2 including leave-one-out analysis, the Cochran Q test, and the Egger intercept test, were conducted.The findings indicated that multiple immune cell phenotypes potentially cause changes in the risk of developing MVP. After adjusting for the false discovery rate, nine immune phenotypes were found to increase the risk of MVP, while nine others appeared to decrease it. In addition, reverse MR analysis found no causal relationship between MVP and these eighteen immunophenotypes.Through genetic analyses, this research demonstrated a significant causal relationship between certain immune cells and MVP, providing new insights for future basic and clinical research.

    Keywords: Mendelian Randomization Analysis, Mitral Valve Prolapse, Genetic approaches, immune cells, Immunophenotypes

    Received: 20 Mar 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Wang, Shen, Tan, Hu, He and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaocong Zeng, Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Region, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.