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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1401586

The clinical characteristics analysis of serum markers for the cardiovascular system in early-stage COVID-19 patients

Provisionally accepted
Xi Cao Xi Cao 1Yong-Li Xie Yong-Li Xie 2Jian-Ying Yi Jian-Ying Yi 1Zhi-Li Liu Zhi-Li Liu 3Dong-Dong Zhang Dong-Dong Zhang 1Yingying Yue Yingying Yue 1Tianning Li Tianning Li 1Chunlei Zhou Chunlei Zhou 1*Hong Mu Hong Mu 1*
  • 1 Tianjin First Central Hospital, Tianjin, China
  • 2 Tianjin Stomatological Hospital, Tianjin, China
  • 3 Tianjin Third Central Hospital, Tianjin, China

The final, formatted version of the article will be published soon.

    Abstract Background: This study aimed to investigate alterations in serum markers (creatine kinase-MB (CKMB), cardiac troponin T (cTnT), myoglobin (Myo), B-type natriuretic peptide (BNP), D-dimer (DD) , procalcitonin (PCT) and interleukin-6 (IL6)) in early Omicron variant infection and analyzed their correlation with clinical parameters. Methods: Retrospective analysis of 1138 mild/asymptomatic cases at Tianjin First Central Hospital, including age, gender, serum markers and nucleic acid test results. Statistical analysis used SPSS software, version 24.0. Results: Elevated cTnT, BNP (125-400), and DD (0.55-1.10) levels were prevalent at 12.92%, 15.64%, and 14.50%, respectively. Females had significantly higher proportions with slightly elevated BNP (19.34%) and DD (19.69%) levels. Patients over 35 had a higher proportion of slight elevation in BNP (20.00%). Abnormal levels of serum markers were significantly associated with older age, increased PCT and IL6 levels, as well as delayed nucleic acid clearance. Additionally, levels of immunoglobulin G (IgG) were notably reduced in these cases. Patients with prolonged nucleic acid clearance (>14 days) had higher BNP and DD levels upon admission. Logistic regression identified PCT (OR=237.95) as the most significant risk factor for abnormal serum markers for cardiovascular system injury. Conclusion: Early Omicron infection might do subclinical damage to the cardiovascular system. Elevated cTnT, BNP and DD levels were correlated with age, gender, inflammatory factors, and IgG. Notably, high PCT level emerged as the most robust predictor of abnormal serum biomarkers.

    Keywords: omicron, cardiovascular system injury, B-type natriuretic peptide, d-dimer, Procalcitonin

    Received: 15 Mar 2024; Accepted: 17 Jul 2024.

    Copyright: © 2024 Cao, Xie, Yi, Liu, Zhang, Yue, Li, Zhou and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chunlei Zhou, Tianjin First Central Hospital, Tianjin, China
    Hong Mu, Tianjin First Central Hospital, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.