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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1399908

Predictive value of Geriatric Nutritional Risk Index in Cardiac and Cerebrovascular Events after Endovascular Aortic Aneurysm Repair

Provisionally accepted
YuPei Zou YuPei Zou 1JiaRong Wang JiaRong Wang 2Ji Chun Zhao Ji Chun Zhao 3YuKui Ma YuKui Ma 3Bin Huang Bin Huang 3Ding Yuan Ding Yuan 3Yang Liu Yang Liu 3MaoNan Han MaoNan Han 3HuaTian Gan HuaTian Gan 1Yi Yang Yi Yang 3*
  • 1 The Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, Chengdu, China., Chengdu, China
  • 2 Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China
  • 3 Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: To evaluate the effect of malnutrition assessed by the Geriatric Nutritional Risk Index (GNRI) on major adverse cardiac and cerebrovascular events (MACCE) in the elderly patients after endovascular aortic aneurysm repair (EVAR). 95% CI -3.88, -0.05, p = 0.0454). GNRI status was associated with a significantly increased risk of long-term mortality after EVAR (Medium GNRI, unadjusted ORHR 0.40, 95%CI 0.23-0.70,p=0.0014; adjusted ORHR 0.47, 95%CI 0.26-0.84, p=0.0107; high GNRI, 0.27 95%CI 0.14-0.55; p=0.0003; adjusted ORHR 0.32 95%CI 0.15-0.68,p= 0.0029). Both medium and high GNRI values were linked to significantly reduced risks of MACCE compared to low GNRI score patients (Medium GNRI, unadjusted ORHR 0.34, 95%CI 0.13-0.88,p=0.00265; adjusted ORHR 0.37, 95%CI 0.14-0.96, p=0.0408; High GNRI, 0.26 95%CI 0.09-0.78; p=0.0168; adjusted ORHR 0.21 95%CI 0.06 -0.73,p= 0.0029, Table 3). Compared with the RCRI and mFI, the GNRI had better discrimination in predicting long-term MACCE. An area under the curve (AUC) for GNRI mFI, and RCRI is 0.707, 0.614 and 0.588, respectively. (Z statistic, GNRI vs mFI, p=0.0475; GNRI vs RCRI, p=0.0017).Malnutrition assessed by the GNRI may serve as a useful predictor of long-term MACCE in elderly patients after EVAR, with preferable discrimination abilities compared with both RCRI and mFI.

    Keywords: Malnutrition, Aged, Abdominal aortic aneurysms, Endovascular Procedures, prognosis

    Received: 12 Mar 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Zou, Wang, Zhao, Ma, Huang, Yuan, Liu, Han, Gan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Yang, Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

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