Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med., 24 October 2024
Sec. Pediatric Cardiology
This article is part of the Research Topic Pediatric and Perinatal Cardiology; Insights, Advances and Updates View all 4 articles

Clinical outcomes of right ventricular outflow tract stenting compared to surgical shunting in late-presenting children

\r\nRadityo Prakoso
Radityo Prakoso1*Resi Citra DewiResi Citra Dewi2Brian Mendel,Brian Mendel1,3Celly Anantaria AtmadikoesoemahCelly Anantaria Atmadikoesoemah4Salomo PurbaSalomo Purba5Damba Dwisepto Aulia SaktiDamba Dwisepto Aulia Sakti1Nanda IryuzaNanda Iryuza6Yovi KurniawatiYovi Kurniawati1Renan Sukmawan\r\nRenan Sukmawan4
  • 1Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia
  • 2Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia
  • 3Department of Cardiology and Vascular Medicine, Sultan Sulaiman Government Hospital, North Sumatera, Indonesia
  • 4Division of Non-Invasive Diagnostic and Cardiovacular Imaging, Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia
  • 5Division of Pediatric and Congenital Heart Surgery, Department of Surgery, National Cardiovascular Centre of Harapan Kita, Universitas Indonesia, Jakarta, Indonesia
  • 6Division of Invasive Cardiology and Non-Surgical Intervention, Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia

Background: Right ventricular outflow tract (RVOT) stenting as an alternative palliation for patients with stenotic RVOTs is increasingly recognized. However, a notable gap remains in the literature regarding the efficacy and the comparative outcomes between RVOT stenting and the modified Blalock-Taussig shunt (mBTS) in children older than one year.

Methods: We conducted a retrospective review of clinical data from patients aged one year to 18 years with stenotic RVOTs who underwent RVOT stenting or mBTS procedures at our institution between December 2019 and October 2022. We compared major adverse cardiovascular events (MACE) including re-hospitalization, re-intervention, and mortality, hospital and ICU length of stay, and discharge oxygen saturation between the groups.

Results: We identified 58 patients (51.7% male) with a median age of 2.6 years (IQR: 2–8.1) and a median weight of 9.7 kg (IQR: 7.5–17.5). Among them, 18 (31%) patients received RVOT stenting, and 40 (68.9%) patients had mBTS. The median age for the RVOT stenting group was 92.5 months (IQR: 31.2–152) compared to 26.5 months (IQR: 23.0–54.0) for the mBTS group (p = 0.218). MACEs occurred in 4 (22.2%) patients with RVOT stents and 8 (20%) patients with mBTS (p = 0.624). Patients with mBTS had a longer ICU stay (median 3.5 days, IQR, 2–5) compared to those with RVOT stents (median 2 days, IQR: 1–2) (p = 0.295). Conversely, the hospital stay for patients with mBTS was shorter (median 10 days, IQR, 7.5–13.7) than for those with RVOT stents (median 11.5 days, IQR, 7–19) (p = 0.045). The median discharge oxygen saturation was 87% (IQR: 83–88) in the mBTS group and 80% (IQR: 75–87) in the RVOT stenting group (p = 0.212).

Conclusions: RVOT stenting as palliation to stenotic RVOTs in children older than one year demonstrated outcomes comparable to mBTS in terms of MACE and achieving oxygen saturation targets.

1 Introduction

Stenotic right ventricular outflow tract (RVOT) lesions with ventricular shunts are the most common form of cyanotic congenital heart disease (1). When definitive surgical repair is not feasible, palliative interventions become essential. The modified Blalock-Taussig shunt (mBTS) is often employed to increase pulmonary blood flow (2). However, previous research has reported high rates of morbidity and mortality, as well as variations in the growth and development of pulmonary arteries associated with the mBTS (3, 4). An emerging palliative approach involves non-surgical interventions, such as ductal stenting and RVOT stenting (3, 5, 6). While some studies have demonstrated positive clinical outcomes with RVOT stenting compared to the mBTS, there is limited research specifically examining the role of RVOT stenting in late presenters, particularly those older than one year (7, 8). Some literature suggests that RVOT stenting not only yields favorable outcomes in older children as a bridging therapy but also serves as a rescue procedure for patients at high surgical risk (8). This study, therefore, aims to compare the initial outcomes of RVOT stenting vs. mBTS in patients aged one to eighteen years with RVOT obstruction and ventricular shunts.

2 Methods

2.1 Study design and population

We conducted a retrospective review of clinical data for all pediatric patients aged one to 18 years with RVOT obstruction and a ventricular shunt who underwent palliative RVOT stenting or mBTS at our institution between December 2019 and October 2022. Ethical approval was granted by the Institutional Review Board of the National Cardiovascular Center Harapan Kita (No. LB.02.01/VII/035/KEP035/2022). The study included patients with congenital heart lesions such as Tetralogy of Fallot (TOF), double outlet right ventricle (DORV) with ventricular septal defect (VSD), and pulmonary stenosis (PS) with VSD. Patients who had undergone single-stage complete repair for TOF or who had single-ventricle physiology (e.g., tricuspid atresia, VSD) were excluded. An anomalous coronary artery course was not considered a contraindication for either RVOT stenting or mBTS. The need for palliative treatment was determined by institutionally recognized risk factors that precluded definitive repair surgery, such as low weight, small pulmonary arteries, and other significant comorbidities. The decision to perform RVOT stenting was primarily influenced by severe comorbidities that posed a high risk for mBTS. Key indications for RVOT stenting included: (1) profound desaturation (typically below 40%–50%), (2) low ejection fraction (LVEF < 40%), (3) high risk associated with performing an mBTS, and (4) high risk for total repair despite adequate pulmonary artery size. All procedures were performed without cardiopulmonary bypass, either electively or emergently, based on clinical judgment.

Patient characteristics before palliation, including age, gender, nutritional status, diagnosis, oxygen saturation, type and average size of the stent or shunt, type of operation, left ventricular ejection fraction (LVEF), and McGoon ratio, were recorded. Intra-procedural and post-procedural data, such as oxygen saturation and complications (e.g., bleeding, stent or shunt failure, sudden cardiac arrest), were also documented. Follow-up assessments were conducted, with all data retrieved from electronic medical records (EMR).

2.2 Study outcome

The primary outcomes focused on major adverse cardiac events (MACE), including rehospitalization and re-intervention. Secondary outcomes included discharge oxygen saturation, length of stay (LOS) in the intensive care unit (ICU), and total hospital LOS.

2.3 Statistical analyses

Categorical data were presented as frequencies (n) and percentages (%). Numerical data were expressed as median and interquartile range (IQR). Chi-square or Fisher's exact tests were used to compare categorical data, while independent Mann-Whitney tests were employed for numerical data analysis. Spearman correlation coefficients were used to evaluate associations between different outcomes. Statistical analyses were performed using the Statistical Package for Social Science (SPSS) version 26.0, with significance set at p < 0.05.

3 Results

3.1 Patient demographics

We identified 58 patients (51.7% male) with a median age of 2.6 years and a median weight of 9.7 kg between December 2019 and October 2022. Of these, 18 patients (31%) received RVOT stenting, while 40 patients (68.9%) had mBTS. Patients in the RVOT stenting group were older, with a median age of 92.5 months compared to 26.5 months for the mBTS group (p = 0.218).

Table 1 shows the baseline characteristics of the groups. There were no significant differences in age, gender, body weight, or nutritional status. Tetralogy of Fallot was the most common diagnosis in both groups. Emergency procedures were more frequent in the RVOT stent group (77.8%) compared to the mBTS group (32.5%). The pre-procedural McGoon ratio was slightly higher in the RVOT stent group (p = 0.745). The median stent size was 9 mm, while the median shunt size was smaller at 4 mm (p = 0.874).

Table 1
www.frontiersin.org

Table 1. Patient demographics and clinical characteristics underwent RVOT stent implantation and mBTS procedure.

3.2 Procedural complications

Several complications occurred during and after the procedures (see Table 2). In the RVOT stenting group, one stent dislodged (5.6%) and required surgical intervention. One patient (11.1%) had cardiac arrest during balloon dilatation, but this was resolved. In the mBTS group, bleeding was controlled during surgery without postoperative issues. Overall, complication rates during the procedures did not differ significantly (p = 0.075).

Table 2
www.frontiersin.org

Table 2. Procedural complications of RVOT stent and mBTS during and post-procedure.

During hospitalization, one patient (5.6%) in the RVOT stenting group experienced restenosis, while shunt failure occurred in 10% of patients in the mBTS group, requiring re-intervention. Bleeding complications were more frequent in the mBTS group, with 5% requiring clot evacuation. Infection rates were higher in the mBTS group at 22.5% (p = 0.593). Major adverse cardiovascular event (MACE) probability was higher in the mBTS group compared to the RVOT stent group (p = 0.704).

3.3 Clinical outcomes

The primary clinical outcome, which included rehospitalization (p = 0.512), re-intervention (p = 0.174), and mortality (p = 0.869), did not differ significantly between the groups (see Table 3). Major adverse cardiac events (MACEs) were slightly higher in the RVOT stenting group, occurring in 22.2% of patients, compared to 20% in the mBTS group (p = 0.624). Rehospitalization due to desaturation occurred in 5.6% of patients in the RVOT stent group. Re-intervention rates were 11.1% in the RVOT stent group and 15% in the mBTS group (p = 0.174). Mortality was observed in one patient (5.6%) in the RVOT stent group due to infection and in two patients (5.0%) in the mBTS group due to shunt thrombosis and low cardiac output, all during hospitalization.

Table 3
www.frontiersin.org

Table 3. Clinical outcome of RVOT stent implantation and mBTS.

The hospital stay was longer in the RVOT stenting group, with a median of 11.5 days compared to 10 days in the mBTS group (p < 0.05). The median ICU stay for the RVOT stenting group was 2 days, compared to 3.5 days for the mBTS group (p = 0.295). Median discharge oxygen saturation was 80% in the RVOT stenting group and 87% in the mBTS group (p = 0.212). Total repair was performed in 50% of the RVOT stent group and 37.5% of the mBTS group. The duration from palliation to total repair was 3 months in the RVOT stent group and 4 months in the mBTS group, with no statistically significant difference between the two (p = 0.289).

4 Discussions

4.1 Late presenters’ characteristics

Our study population predominantly comprised late presenters (79), a stark contrast to previous studies that focused on younger age groups (1012). This discrepancy is primarily due to diagnostic and management limitations, as well as a shortage of pediatric cardiologists and cardiac surgeons. Most of our patients were diagnosed with Tetralogy of Fallot (TOF), and their older age at presentation mirrors findings from studies in regions with limited healthcare access. In Indonesia, 86.2% of patients with cyanotic congenital heart disease (CHD) were diagnosed late, with TOF being the most common diagnosis (13). Late presenters often exhibit hypertrophy of the infundibulum, making implanted stents more prone to fracture (79).

4.2 RVOT stenting advantages

RVOT stenting offers several advantages for patients with Tetralogy of Fallot (TOF), particularly those who present late (79). In our study, RVOT stenting was not associated with a significant increase in major adverse cardiac events (MACE), with rates similar to those observed in the mBTS group. A key benefit of RVOT stenting was the shorter length of stay in both the ICU and hospital overall. Patients in the RVOT stent group had a significantly shorter median ICU stay, and total hospital stays were also reduced compared to those in the mBTS group. Additionally, discharge oxygen saturation levels were adequate in the RVOT stent group, indicating that the procedure effectively improved pulmonary blood flow without negatively affecting clinical outcomes (1012).

These findings align with previous studies, such as those by Abumehdi et al. (14) and Quandt et al. (5), which reported similar reductions in ICU length of stay following RVOT stenting. Abumehdi et al. (14) reported a median ICU stay of 2 days, while Quandt et al. (5) found a median stay of 0 days, with only 22% of RVOT stent patients requiring post-procedural ICU admission. RVOT stent implantation directly channels blood flow from the right ventricle into the pulmonary circulation, improving oxygenation without compromising aortic diastolic perfusion pressure. This contributes to enhanced hemodynamic stability, leading to shorter ICU stays and overall reduced hospitalization times (1012).

4.3 RVOT stenting technical difficulties

While RVOT stenting offers several advantages, it also presents significant technical challenges (15). In our study, complications such as stent dislodgement and cardiac arrest during balloon dilation were observed, highlighting the critical need for technical proficiency and meticulous procedural planning. Although mortality rates were comparable between the RVOT stenting and mBTS groups, the RVOT stent patients were often in more severe preoperative conditions, which may have contributed to postoperative complications and mortality. Importantly, however, no deaths in our cohort were directly attributable to the RVOT stenting procedure.

Currently, no stents are specifically designed or approved for use in pediatric patients (16). Nevertheless, stent implantation has emerged as a viable short-term solution for infants and small children with native or post-surgical branch pulmonary artery stenosis. Despite this, certain challenges persist due to the small vessel size, limited vascular access, and the ongoing growth of pediatric patients, which can result in restenosis at the stent site. Intimal hyperplasia is a common complication following stent placement (16).

An ideal stent for pediatric use would need to be crimped onto small balloons, have a low-profile delivery system, offer sufficient radial strength, resist intimal hyperplasia, and have the capacity to be expanded to adult dimensions while maintaining structural integrity. Haddad et al. (2023) demonstrated the safe implantation and efficacy of 3 Optimus-L stents (AndraTec, Koblenz, Germany) using a low-profile approach in small patients (16).

In our study, the presence of an anomalous coronary artery course was not considered a contraindication to RVOT stenting, despite the inherent risks. A key limitation of the procedure is the close proximity of coronary branches to the anticipated landing zone of the pulmonary valve, which raises concerns about coronary compression due to the radial force exerted by the balloon-expandable stent. This risk is particularly significant for patients with the left anterior descending (LAD) artery originating from the right aortic sinus, as the LAD crosses near the RVOT (17). However, Hanser et al. (17) (2022) assessed outcomes of RVOT stenting in TOF patients with anomalous coronary courses, finding no mortality in their cohort despite the presence of these anomalies. Out of 122 TOF patients, 10 had coronary anomalies, with 6 requiring reintervention and 1 undergoing early surgical palliation due to suboptimal stent placement. Their findings indicate that RVOT stenting remains a safe and effective option in such cases (17).

4.4 Expected outcomes

According to Martins et al. (18), the ideal timing for definitive corrective surgery during the first year of life is typically between 3 and 6 months for asymptomatic or mildly symptomatic children. However, our study population differs significantly in terms of age, with many patients presenting late (79). For patients who receive RVOT stents, the long-term management strategy often involves a staged approach to definitive repair, with the timing guided by the size of the pulmonary arteries, typically assessed using a McGoon ratio of 1.5 or higher. In some instances, mBTS or RVOT stenting may still be performed even when the McGoon ratio exceeds 1.5 to ensure sufficient pulmonary artery development. Patients with RVOT stents usually remain clinically stable until they are ready for total repair (19, 20). Our findings further support RVOT stenting as a safe and effective bridge to definitive surgical correction in late-presenting TOF patients, facilitating better planning for surgery once the patient is in a more favorable clinical condition. The limited number of completed repairs can be attributed to patients feeling clinically improved and thus declining further procedures. This issue is exacerbated by the complex and lengthy queuing system within the healthcare framework, leading to extended wait times at national referral centers. Despite these challenges, we strive to maintain follow-up through clinic visits and direct communication with patients.

5 Limitations

This investigation relied on retrospective data sourced from registries or medical records, necessitating meticulous attention to the accuracy and comprehensiveness of the records. Patient selection was consecutive, with individuals not randomized into intervention groups but rather chosen based on clinical and surgical risk evaluations. Notably, the sample size within the RVOT stent group remains constrained.

6 Conclusions

RVOT stenting as a palliation to stenotic RVOTs in children showed comparable outcomes to mBTS in terms of MACE and achievement of oxygen saturation targets in patients older than one year.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Ethics statement

The studies involving humans were approved by Institutional Review Board of National Cardiovascular Center Harapan Kita No. LB.02.01/VII/035/KEP035/2022. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin.

Author contributions

RP: Conceptualization, Data curation, Formal Analysis, Project administration, Writing – original draft, Writing – review & editing. RC: Methodology, Project administration, Software, Writing – original draft, Writing – review & editing. BM: Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing. CA: Writing – original draft, Writing – review & editing. SP: Writing – original draft, Writing – review & editing. DS: Writing – original draft, Writing – review & editing. NI: Writing – original draft, Writing – review & editing. YK: Writing – original draft, Writing – review & editing. RS: Writing – original draft, Writing – review & editing.

Funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

Acknowledgments

We extend our appreciation to all who contributed to the development of this study. We offer special thanks to Putra Habibie Adnantama Lubis and Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, for their invaluable support.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1. Mendel B, Kohar K, Yumnanisha DA, Djiu RJ, Winarta J, Prakoso R, et al. Impact of fetal pulmonary valvuloplasty in in-utero critical pulmonary stenosis: a systematic review and meta-analysis. Int J Cardiol CHD. (2024) 15(2024):100485. doi: 10.1016/j.ijcchd.2023.100485

Crossref Full Text | Google Scholar

2. Quandt D, Ramchandani B, Penford G, Stickley J, Bhole V, Mehta C, et al. Right ventricular outflow tract stent versus BT shunt palliation in tetralogy of fallot. Heart. (2017) 103:1985–91. doi: 10.1136/heartjnl-2016-310620

PubMed Abstract | Crossref Full Text | Google Scholar

3. Prakoso R, Simanjorang CNS, Kurniawati Y, Mendel B, Rahmat B, Zahara R, et al. Ductal stenting vs. surgical shunting in late presenting duct-dependent pulmonary circulation: a single-center experience. Front Cardiovasc. Med. (2024) 11:1382879. doi: 10.3389/fcvm.2024.1382879

PubMed Abstract | Crossref Full Text | Google Scholar

4. Ghaderian M, Ahmadi A, Sabri MR, Behdad S, Dehghan B, Mahdavi C, et al. Clinical outcome of right ventricular outflow tract stenting versus Blalock-Taussig shunt in tetralogy of Fallot: a systematic review and meta-analysis. Curr Probl Cardiol. (2021) 46(3):100643. doi: 10.1016/j.cpcardiol.2020.100643

PubMed Abstract | Crossref Full Text | Google Scholar

5. Quandt D, Penford G, Ramchandani B, Bhole V, Mehta C, Stumper O. Stenting of the right ventricular outflow tract as primary palliation for Fallot-type lesions. J Congenit Hear Dis. (2017) 3:1–6. doi: 10.1186/s40949-017-0005-7

Crossref Full Text | Google Scholar

6. Haddad RN, Hanna N, Charbel R, Daou L, Chehab G, Saliba Z. Ductal stenting to improve pulmonary blood flow in pulmonary atresia with intact ventricular septum and critical pulmonary stenosis after balloon valvuloplasty. Cardiol Young. (2019) 29(4):492–8. doi: 10.1017/S1047951119000118

PubMed Abstract | Crossref Full Text | Google Scholar

7. Prakoso R, Kurniawati Y, Siagian SN, Sembiring AA, Sakti DDA, Mendel B, et al. Right ventricular outflow tract stenting for late presenter unrepaired Fallot physiology: a single-center experience. Front Cardiovasc Med. (2024) 11:1340570. doi: 10.3389/fcvm.2024.1340570

PubMed Abstract | Crossref Full Text | Google Scholar

8. Prakoso R, Kurniawati Y, Siagian SN, Sembiring AA, Sakti DDA, Mendel B, et al. Percutaneous palliative stenting option in adults with unrepaired tetralogy of Fallot. JACC Adv. (2024):1–3. doi: 10.1016/j.jacadv.2024.101073

Crossref Full Text | Google Scholar

9. Prakoso R, Agita Sembiring A, Sakti DDA, Mendel B. Lilyasari O double stenting in 19-year-old patient with tetralogy of Fallot with prior fractured stent. J Am Coll Cardiol Case Rep. (2022) 4(20):1375–8. doi: 10.1016/j.jaccas.2022.07.043

Crossref Full Text | Google Scholar

10. Sandoval J, Chaturvedi R, Chir MB, Benson L, Morgan G, Arsdell G, et al. Right ventricular outflow tract stenting in tetralogy of Fallot infants with risk factors for early primary repair. Circ Cardiovasc Interv. (2016) 9:1–4. doi: 10.1161/CIRCINTERVENTIONS.116.003979

Crossref Full Text | Google Scholar

11. Luxford JC, Adams PE, Roberts PA, Mervis J. Right ventricular outflow tract stenting is a safe and effective bridge to definitive repair in symptomatic infants with tetralogy of Fallot. Heart Lung Circ. (2023) 32(5):638–44. doi: 10.1016/j.hlc.2023.02.010

PubMed Abstract | Crossref Full Text | Google Scholar

12. Pizzuto A, Cuman M, Assanta N, Franchi E, Marrone C, Pak V, et al. Right ventricular outflow tract stenting as palliation of critical tetralogy of Fallot: techniques and results. Heart. (2021) 2:278–87. doi: 10.3390/hearts2020022

Crossref Full Text | Google Scholar

13. Murni IK, Wirawan MT, Patmasari L, Sativa ER, Arafuri N, Nugroho S, et al. Delayed diagnosis in children with congenital heart disease: a mixed-method study. BMC Pediatr. (2021) 21(1):1–7. doi: 10.1186/s12887-021-02667-3

PubMed Abstract | Crossref Full Text | Google Scholar

14. Abumehdi M, Sasikumar D, Chaudhari M, Bhole V, Botha P, Mehta C, et al. Stenting of the right ventricular outflow tract as an initial intervention in tetralogy of Fallot with pulmonary stenosis and major aortopulmonary collateral arteries. Cardiol Young. (2021) 31:452–9. doi: 10.1017/S1047951120004278

PubMed Abstract | Crossref Full Text | Google Scholar

15. Bigdelian H, Ghaderian M, Sedighi M. Surgical repair of tetralogy of Fallot following primary palliation: right ventricular outflow tract stenting versus modified Blalock-Taussig shunt. Indian Heart J. (2018) 70:S394–398.30595296

PubMed Abstract | Google Scholar

16. Haddad RN, Eicken A, Adel Hassan A, Gendera K, Kasem M, Georgiev S. Proof of concept: a new solution for low-profile transcatheter implantation of Optimus-L stents in small children. Can J Cardiol. (2024) 40(1):77–86. doi: 10.1016/j.cjca.2023.09.015

PubMed Abstract | Crossref Full Text | Google Scholar

17. Hanser A, Michel J, Hornung A, Sieverding L, Hofbeck M. Coronary artery anomalies and their impact on the feasibility of percutaneous pulmonary valve implantation. Pediatr Cardiol. (2022) 43(1):8–16. doi: 10.1007/s00246-021-02684-0

PubMed Abstract | Crossref Full Text | Google Scholar

18. Martins IF, Doles IC, Bravo-Valenzuela NJM, Santos AORD, Varella MSP. When is the best time for corrective surgery in patients with tetralogy of Fallot between 0 and 12 months of age? Braz J Cardiovasc Surg. (2018) 33(5):505–10. doi: 10.21470/1678-9741-2018-0019

PubMed Abstract | Crossref Full Text | Google Scholar

19. Zhou T, Wang Y, Liu J, Wang Y, Wang Y, Chen S, et al. Pulmonary artery growth after modified Blalock-Taussig shunt: a single center experience. Asian J Surg. (2020) 43(2):428–37. doi: 10.1016/j.asjsur.2019.06.002

PubMed Abstract | Crossref Full Text | Google Scholar

20. Bhat SPS, Prasannakumar CS. Novel technique of achieving hemodynamic stability during systemic to pulmonary artery shunt. Indian J Thorac Cardiovasc Surg. (2021) 37(6):722–5. doi: 10.1007/s12055-021-01245-7

PubMed Abstract | Crossref Full Text | Google Scholar

Keywords: developing country, fallot tetralogy, late-presenter, modified Blalock-Taussig shunt, RVOT obstruction, stent

Citation: Prakoso R, Citra Dewi R, Mendel B, Atmadikoesoemah CA, Purba S, Sakti DDA, Iryuza N, Kurniawati Y and Sukmawan R (2024) Clinical outcomes of right ventricular outflow tract stenting compared to surgical shunting in late-presenting children. Front. Cardiovasc. Med. 11:1395132. doi: 10.3389/fcvm.2024.1395132

Received: 3 March 2024; Accepted: 10 October 2024;
Published: 24 October 2024.

Edited by:

Edward Araujo Júnior, Federal University of São Paulo, Brazil

Reviewed by:

Nathalie Jeanne M. Bravo-valenzuela, Federal University of Rio de Janeiro, Brazil
Raymond N. Haddad, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), France

Copyright: © 2024 Prakoso, Citra Dewi, Mendel, Atmadikoesoemah, Purba, Sakti, Iryuza, Kurniawati and Sukmawan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Radityo Prakoso, karajanh70@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.