AUTHOR=Sun Yu , Xu Han , Gao Weihan , Deng Jinlan , Song Xiayinan , Li Jie , Liu Xijian 

TITLE=S100a8/A9 proteins: critical regulators of inflammation in cardiovascular diseases

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1394137

DOI=10.3389/fcvm.2024.1394137

ISSN=2297-055X

ABSTRACT=<p>Neutrophil hyperexpression is recognized as a key prognostic factor for inflammation and is closely related to the emergence of a wide range of cardiovascular disorders. In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease. This article evaluates the utility of S100A8/A9 protein as a biomarker and therapeutic target for diagnosing cardiovascular diseases, considering its structural features, fundamental biological properties, and its multifaceted influence on cardiovascular conditions including atherosclerosis, myocardial infarction, myocardial ischemia/reperfusion injury, and heart failure.</p>