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REVIEW article

Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1394137

S100A8/A9 Proteins: Critical Regulators of Inflammation in Cardiovascular Diseases

Provisionally accepted
Sun Yu Sun Yu 1Han Xu Han Xu 2GAO Weihan GAO Weihan 3Deng Jinlan Deng Jinlan 3Xiayinan Song Xiayinan Song 2Jie Li Jie Li 2*Xijian Liu Xijian Liu 4*
  • 1 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan,, China
  • 3 Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 4 College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Neutrophil hyperexpression is recognized as a key prognostic factor for inflammation and is closely related to the emergence of a wide range of cardiovascular disorders. In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease. This article evaluates the utility of S100A8/A9 protein as a biomarker and therapeutic target for diagnosing cardiovascular diseases, considering its structural features, fundamental biological properties, and its multifaceted influence on cardiovascular conditions including atherosclerosis, myocardial infarction, myocardial ischemia/reperfusion injury, and heart failure.

    Keywords: cardiovascular disease, S100A8/A9 protein, Inflammation, Neutrophil, biomarker

    Received: 01 Mar 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Yu, Xu, Weihan, Jinlan, Song, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jie Li, Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan,, China
    Xijian Liu, College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.