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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1392548

The value of phenylalanine in predicting atrial fibrillation risk in chronic heart failure

Provisionally accepted
Qing Fen Zhou Qing Fen Zhou 1*Qiuya Lu Qiuya Lu 2Yang Dai Yang Dai 3Qiujing Chen Qiujing Chen 3Xiao-Shuang He Xiao-Shuang He 4Shuai Chen Shuai Chen 3Jun-Tao Zhao Jun-Tao Zhao 2Feng-Ru Zhang Feng-Ru Zhang 1Lin Lu Lin Lu 1Fan Yang Fan Yang 2
  • 1 Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 2 Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • 3 Institute of Cardiovascular Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 4 Department of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

The final, formatted version of the article will be published soon.

    Backgrounds Atrial fibrillation (AF) is a common complication of chronic heart failure (HF). Serum phenylalanine (Phe) levels is related to inflammation disorder. It is meaningful to study the circulating Phe with AF occurrence in HF.The cross-sectional study recruited 300 patients (78.0% male, mean age 65 ±1 3 years) with HF (left ventricular ejection fraction≤50%, containing 70 AF patients) and 100 normal controls. Serum Phe value was measured by liquid chromatographytandem mass spectrometry. Logistic regression analysis was conducted to measure the association between Phe and AF risk in HF. The association between Phe and highsensitivity C-reactive protein (hsCRP) was assessed by simple correlation analysis. In the prospective study, the 274 HF subjects (76.6% males, mean age 65 ±13 years) were followed up for a mean year (10.99±3.00 months).Serum Phe levels were increased along with the control, the HF without AF, and the HF with AF groups (77.60±8.67 umol/L vs. 95.24±28.58 umol/L vs. 102.90±30.43 umol/L, Avona P<0.001). Serum Phe value was the independent risk factor for predicting AF in HF [odds ratio, 1.640; 95% confidence interval (CI): 1.150-2.339; P = 0.006]. Phe levels were correlated positively with hsCRP value in HF patients with AF (r = 0.577, P<0.001). The elevated Phe levels were associated with a higher risk of HF endpoint events in HF patients with AF (Log-rank P=0.005).In HF with AF subjects, elevated Phe value confers an increased risk for prediction AF and was more related to poor HF endpoint events. Phe can be a valuable index of AF in HF.

    Keywords: chronic heart failure, Atrial Fibrillation, Phenylalanine, risk prediction, Inflammatory disorder, prognosis

    Received: 27 Feb 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Zhou, Lu, Dai, Chen, He, Chen, Zhao, Zhang, Lu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qing Fen Zhou, Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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