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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Thrombosis and Haemostasis
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1384930
Combined Endovascular Interventions for Pulmonary Embolism at High Altitude in Tibet
Provisionally accepted
Tengyan Yang
1
Jian Yang
2*- 1 Changdu People 's Hospital, Tibet, China
- 2 Gastroenterology Department, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Background: Managing pulmonary embolism (PE) at extremely high altitudes poses unique challenges due to harsh environmental conditions and limited healthcare resources. Method: This study retrospectively analyzed Tibetan PE patients in the Tibet Autonomous Region of China to evaluate the effectiveness and safety of combined endovascular interventional therapy in high-altitude areas. Results: The average altitude of long-term residence for Tibetan patients was 3863.4 ± 317.4 m, with an average age of 62.0 ± 16.0 years, and the time from computed tomography pulmonary angiography (CTPA) diagnosis to interventional treatment averaged 2.8 ± 2.2 days. The operation time for these patients was 106.1 ± 22.2 minutes, and the intraoperative dose of alteplase used was 23.3 ± 5.0 mg. All 9 patients reported profound remission of dyspnea and chest pain after endovascular interventions. The heart rate (p＜0.05) and respiratory rate (p＜0.001) of all enrolled patients were significantly decreased, and the peripheral capillary oxygen saturation (SpO2) was significantly increased (p＜0.05) after interventions. No severe complications, such as bleeding, occurred in any patient. Conclusion: This study demonstrated the potential clinical benefits and feasibility of combined endovascular interventional therapy for treating acute PE in extreme high-altitude regions.
Keywords: Pulmonary Embolism, high altitude, Endovascular intervention, effectiveness, Safety, Tibet
Received: 22 Feb 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Yang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jian Yang, Gastroenterology Department, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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