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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1382585
This article is part of the Research Topic Insights in Coronary Artery Disease: 2023 View all 9 articles

Sex Related Disparities after Complex Percutaneous Coronary Interventions

Provisionally accepted

The final, formatted version of the article will be published soon.

    Introduction: Complex Percutaneous coronary intervention (PCI) for the treatment of ischemic heart disease has increased significantly. We aimed to evaluate sex-related differences in patients undergoing complex PCI. Methods: single-center prospective observational study including patients undergoing complex PCI between 2017 and 2023. Baseline and procedural features, and mid-term outcomes were compared according to the gender distribution. The combined primary endpoint included stroke, myocardial infarction, need for a new coronary revascularization, and all-cause mortality. Propensity score (PS) matching with an inverse probability of treatment weight (IPW) approach was used to adjust for differences in baseline characteristics. Results: 1,283 patients were included, 983 (76.6%) male and 300 (23.4%) female. Median follow-up was 2.4 (IQR: 1-3.8) years. There was a higher rate of no-reflow phenomenon (4% vs 1.8%, p=0.03) among female patients. In the overall cohort, female patients had a greater risk for the combined primary endpoint (HR 1.28, 95%CI 1.02-1.59). In the matched cohort, female patients exhibited a higher risk for the combined primary endpoint (HR 1.23, 95%CI: 1.06-1.42), as well as for myocardial infarction (HR 1.34, 95%CI 1.03-1.75), and all-cause mortality (HR 1.21, 95%CI 1.02-1.45), and a trend towards a higher risk for the need of a new coronary revascularization (HR 1.22, 95%CI 0.92-1.61). Conclusions: in a contemporary cohort of patients undergoing complex PCI procedures, female patients are associated with a higher risk of early complications.

    Keywords: Coronary Artery Disease, Percutaneous Coronary Intervention, complex PCI, Myocardial Infarction, sex-related differences inverse probability of treatment weight. LVEF: left ventricular ejection fraction percutaneous coronary intervention PS: propensity-score

    Received: 05 Feb 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Alperi, Almendarez, Pascual, Alvarez, Betanzos, Hernandez-Vaquero, Ptaszynski, Ortiz, Moris and Avanzas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Alberto Alperi, Central University Hospital of Asturias, Oviedo, Spain
    Isaac Pascual, Central University Hospital of Asturias, Oviedo, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.