Dayu Sun
Rajesh Katare
Palaniappan Sethu
Panke Cheng
Yonghong Fan- 1Department of Anatomy, Third Military Medical University, Chongqing, China
- 2Department of Physiology, HeartOtago, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
- 3Division of Cardiovascular Disease, Department of Medicine and Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States
- 4Institute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
- 5Laboratory of Basic Medicine, The General Hospital of Western Theater Command, Chengdu, China
Editorial on the Research Topic
Constructing the vascular or cardiac tissue and organoids: the combination of biomedicine and engineering
Cardiovascular diseases (CVD) are the most prevalent noncommunicable conditions and remain the leading cause of death worldwide (1, 2). Despite pharmacotherapy being the first-line treatment (3), surgical repair or replacement is recognized as an indispensable therapy for patients with severe CVD. Due to the shortage of donors and immune responses, bioengineered vascular tissue and cardiac tissue are promising strategies to solve these problems (4, 5).
Tissue engineering utilizes the principles of engineering and life sciences to the generation of biological substitutes (6). Its key elements consist of cell sources, scaffolds, biochemical cues, and fabrication techniques (7). With cutting-edge technology in biomedicine and engineering, such as organoids (8), microfludics (9), and organ-on-a-chip (10), scientists are attempting to biofabricate functional and physiologically-relevant tissues, and even organs.
Based on this topic, the compilation includes three review articles and one original research article, exploring the progress in bioengineered vascular tissue and bioengineered cardiac tissue.
Bioengineered vascular tissue
Traditional vascular grafts include synthetic conduits, xenografts of animal origin, cadaveric allografts, and autografts from patients' own bodies. They have limited supplies and frequent complications due to mechanical stress, inflammatory responses, and inconsistent remodeling. In comparison, bioengineered vascular tissue has the potential to overcome the issues mentioned above, be remodeled by the host into native tissue, and even grow with young patients (11).
The review by Leal et al. encompasses the development, manufacturing techniques, fabricating materials, in vivo animal studies, and clinical trials of small-caliber vascular grafts. From their perspective of cardiac surgeons, the cell-free scaffold-based small-diameter TEVG made from biocompatible polymers would meet the significant clinical demand. A variety of materials' unique features and properties are classified, and a combination of these polymers, as well as scaffold modifications with biomolecules and functional cells, are suggested. This might contribute to creating ideal and practical small-caliber vascular grafts.
Campanile et al. summarize the niche structure, function, and in vitro model of the bone marrow vasculature, and compare cellular mobilization and homing in the Bone Marrow via its vasculature in both cardiovascular disease and cancer. The researchers propose that a more efficient in vitro model should incorporate a monolayer of endothelial cells within a fluid flow environment, along with perivascular cells, of human origin and derived from bone marrow.
Bioengineered cardiac tissue
Cardiac tissue engineering has been a major focus of the tissue engineering field. Since the adult heart lacks the ability to generate, implantation of cells and bioengineered cardiac patches is employed to repair the damaged myocardium (12). Progress in fabrication techniques, tissue maturation, vascularization and perfusion, and high-throughput platforms will propel bioengineered cardiac tissue toward true clinical and industrial application (13).
Birla summarizes the advancements in ventricle tissue engineering and identifies four main biofabrication strategies for bioengineering ventricles: bioprinting, pull-spinning, utilizing balloon catheters, and utilizing custom molds. In addition to fabrication technology, further progress in biomaterials, cell sourcing, and bioreactor technology would expedite the advancement of this field and bridge the functional gap between bioengineered and human ventricles.
Reyat et al. have developed a method to create vascularized and chamber-specific cardiac microtissues by combining atrial or ventricular cardiomyocytes from hiPSC with vascular sprouts from human blood vessel organoids. The gene expression signatures, architectural structure, and electrophysiological properties of the microtissues are comparable to those of in vivo-derived cardiac tissues. Pro-fibrotic stimulation recapitulated the features of cardiac fibrosis. However, the phenotype can be reversed by the receptor inhibitor, indicating the potential of cardiac microtissues in disease modelling and pharmacological screening.
Conclusion
These articles and reviews on the topic show that it is very promising to treat cardiovascular disease with bioengineered vascular or cardiac tissues and organoids. The advancements in both biomedicine and engineering, as well as their further collaboration, would lead to improved treatments for cardiovascular disease.
Author contributions
DS: Writing – original draft, Writing – review & editing. RK: Writing – review & editing. PS: Writing – review & editing. PC: Writing – review & editing. YF: Writing – review & editing.
Acknowledgment
We acknowledge the co-authors of this collection for their intellectual contribution.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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References
1. Global Cardiovascular Risk Consortium. Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med. (2023) 389:1273–85. doi: 10.1056/NEJMoa2206916
2. Cosselman KE, Navas-Acien A, Kaufman JD. Environmental factors in cardiovascular disease. Nat Rev Cardiol. (2015) 12:627–42. doi: 10.1038/nrcardio.2015.152
3. Tomaniak M, Katagiri Y, Modolo R, de Silva R, Khamis RY, Bourantas CV, et al. Vulnerable plaques and patients: state-of-the-art. Eur Heart J. (2020) 41:2997–3004. doi: 10.1093/eurheartj/ehaa227
4. O’Connor C, Brady E, Zheng Y, Moore E, Stevens KR. Engineering the multiscale complexity of vascular networks. Nat Rev Mater. 7:702–16. doi: 10.1038/s41578-022-00447-8
5. Yadid M, Oved H, Silberman E, Dvir T. Bioengineering approaches to treat the failing heart: from cell biology to 3D printing. Nat Rev Cardiol. (2022) 19:83–99. doi: 10.1038/s41569-021-00603-7
6. Langer R, Vacanti JP. Tissue engineering. Science. (1993) 260:920–6. doi: 10.1126/science.8493529
7. Sun L, Wang Y, Xu D, Zhao Y. Emerging technologies for cardiac tissue engineering and artificial hearts. Smart Med. (2023) 2:e20220040. doi: 10.1002/SMMD.20220040
8. Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science. (2014) 345:1247125. doi: 10.1126/science.1247125
9. Zheng W, Jiang X. Synthesizing living tissues with microfluidics. Acc Chem Res. (2018) 51:3166–73. doi: 10.1021/acs.accounts.8b00417
10. Zhao Y, Wang EY, Lai FBL, Cheung K, Radisic M. Organs-on-a-chip: a union of tissue engineering and microfabrication. Trends Biotechnol. (2023) 41:410–24. doi: 10.1016/j.tibtech.2022.12.018
11. Naegeli KM, Kural MH, Li Y, Wang J, Hugentobler EA, Niklason LE. Bioengineering human tissues and the future of vascular replacement. Circ Res. (2022) 131:109–26. doi: 10.1161/CIRCRESAHA.121.319984
12. Murry CE, MacLellan WR. Stem cells and the heart-the road ahead. Science. (2020) 367:854–5. doi: 10.1126/science.aaz3650
Keywords: vessel, cardiac function, heart, bioengineering, tissue engineering, organoid, biomaterials, manufacturing
Citation: Sun D, Katare R, Sethu P, Cheng P and Fan Y (2024) Editorial: Constructing the vascular or cardiac tissue and organoids: the combination of biomedicine and engineering. Front. Cardiovasc. Med. 11:1371074. doi: 10.3389/fcvm.2024.1371074
Received: 15 January 2024; Accepted: 5 February 2024;
Published: 16 February 2024.
Edited and Reviewed by: Ngan F. Huang, Stanford University, United States
© 2024 Sun, Katare, Sethu, Cheng and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Dayu Sun ZGF5dXN1bjEwMjhAMTYzLmNvbQ==