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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1370307
Evaluation of the effect of kidney transplantation on left ventricular myocardial work by noninvasive pressure-strain loops
Provisionally accepted
Han Zhengyang
1,2
Lingyun Wang
3
Honghu Wang
3
Hongying He
3
Yi Song
3
Menghe Wang
3
Na Zhao
3
Zhengguang Chen
3
Zhenxing Sun
1*
Shan Zhang
3*- 1 Huazhong University of Science and Technology, Wuhan, China
- 2 Ultrasound, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 3 First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
Kidney transplantation (KT) has the potential to reverse the cardiac changes caused by end-stage renal disease, and it may be inaccurate to analysis the left ventricular function by conventional echocardiography due to afterload. This study aimed to investigate the utility of pressure strain loops (PSLs) in evaluating left ventricular performance in patients underwent KT.We enrolled 60 patients with end-stage renal disease who underwent KT between January 2022 and July 2023, and 60 healthy controls with a similar distribution of gender and age to the patients.All participants underwent conventional echocardiography and three-dimensional speckle tracking echocardiography (3D-STE). Long axis, short axis, and four cavity images were collected and cardiac parameters were measured. The echocardiographic changes of cardiac structure and function of all patients before KT and about 12 months after KT were recorded. Left ventricular myocardial work parameters were acquired by PSLs, including the global work index (GWI), global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE) and global longitudinal strain (GLS). In addition, the correlation between PSLs and clinical data were explored.Compared with controls, the conventional echocardiographic parameters, myocardial function indicators GWI and GCW appeared no difference in post-KT group, while the GWE and GLS decreased (p<0.05), and the GWW increased (p<0.05). Compared with pre-KT, the GLS, GWI, GCW and GWE increased in post-KT group, while the GWW decreased (all p<0.05). The above indicators were correlated with left ventricular GLS and left ventricular ejection fraction.PSLs were more sensitive than traditional echocardiographic indicators in detecting changes in myocardial work and predicting left ventricular myocardial damage. This indicator could quantitatively evaluate myocardial work and provide a new and reliable non-invasive reference for clinical diagnosis and treatment of patients underwent KT.
Keywords: Kidney Transplantation, Echocardiography, myocardial work, Three-dimensional speckle tracking echocardiography, Pressure-strain loops
Received: 14 Jan 2024; Accepted: 17 Jul 2024.
Copyright: © 2024 Zhengyang, Wang, Wang, He, Song, Wang, Zhao, Chen, Sun and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhenxing Sun, Huazhong University of Science and Technology, Wuhan, China
Shan Zhang, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
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