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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1366316
This article is part of the Research Topic Contemporary Percutaneous Interventions for Coronary Chronic Total Occlusions View all 7 articles

Association between Hibernating Myocardium and Collateral Circulation in Patients with Coronary Chronic Total Occlusion

Provisionally accepted
Yaqi Liu Yaqi Liu 1Yongjun Chen Yongjun Chen 2Feifei Zhang Feifei Zhang 1Bao Liu Bao Liu 1Jianfeng Wang Jianfeng Wang 1Mei Xu Mei Xu 1Yuetao Wang Yuetao Wang 1*Xiaoliang Shao Xiaoliang Shao 1*
  • 1 Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, China
  • 2 Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China

The final, formatted version of the article will be published soon.

    Objective: To explore the association between the quantity of hibernating myocardium (HM) and collateral circulation in patients with coronary chronic total occlusion (CTO).Materials and Methods: 88 CTO patients were retrospectively analyzed who underwent evaluation for HM using both 99m Tc-sestamibi Single photon emission computed tomography ( 99m Tc-MIBI SPECT) myocardial perfusion imaging (MPI) combined with 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) myocardial metabolism imaging (MMI). They were divided into two groups according Rentrop grading: the poorly/well-developed collateral circulation group (PD/WD group, Rentrop grades 0-1/2-3). After adjusting for the potential confounding factors and conducting a stratified analysis, we explored the association between the HM index within CTO region and the grading of collateral circulation.In the WD group, the HM index was notably higher than PD group (46.2±15.7% vs. 20.9±16.7%, P<0.001). When dividing the HM index into tertiles and after adjusting for potential confounders, we observed that the proportion of patients with WD rose as the HM index increased (OR: 1.322, 95% CI: 0.893-1.750, P<0.001), the proportion of patients with WD was 17.4%, 63.3%, and 88.6% for Tertile 1 to Tertile 3.This increasing trend was statistically significant (OR: 1.369, 95% CI: 0.873-1.864, P<0.001), especially between Tertile 3 versus Tertile 1 (OR: 4.330, 95% CI: 1.459-12.850, P=0.008). Curve fitting displaying an almost linear positive correlation between the two.The HM index within CTO region is an independent correlation factor for the grading of coronary collateral circulation. A greater HM index corresponded to an increased likelihood of WD.

    Keywords: Coronary Artery Disease, chronic total occlusion, Collateral Circulation, Hibernating myocardium, Association

    Received: 06 Jan 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Liu, Chen, Zhang, Liu, Wang, Xu, Wang and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuetao Wang, Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, China
    Xiaoliang Shao, Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, China

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