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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1358601
This article is part of the Research Topic Novel Translational Advances in Hemodynamics for the Diagnosis and Treatment of Cardiovascular Diseases View all 11 articles

Development of idealized human aortic models for in-vitro and in-silico hemodynamic studies

Provisionally accepted
Hamid Mansouri Hamid Mansouri 1Muaz Kemerli Muaz Kemerli 1,2Robroy Maciver Robroy Maciver 3Omid Amili Omid Amili 1*
  • 1 University of Toledo, Toledo, Ohio, United States
  • 2 Sakarya University, Sakarya, Sakarya, Türkiye
  • 3 Children's Minnesota Hospitals and Clinics, Minneapolis, Minnesota, United States

The final, formatted version of the article will be published soon.

    Background: The aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies. Objective: This study aims to develop computer-aided design (CAD) models for the idealized human aorta, intended for studying hemodynamics or solid mechanics in both in-vitro and in-silico settings. Methods: Various parameters were extracted from comprehensive literature sources to evaluate major anatomical characteristics of the aorta in healthy adults, including variations in aortic arch branches and corresponding dimensions. The idealized models were generated based on averages weighted by the cohort size of each study for several morphological parameters collected and compiled from image-based or cadaveric studies, as well as data from four recruited subjects. The models were used for hemodynamics assessment using particle image velocimetry (PIV) measurements and computational fluid dynamics (CFD) simulations. Results: Two CAD models for the idealized human aorta were developed, focusing on the healthy population. The CFD simulations, which align closely with the PIV measurements, capture the main global flow features and wall shear stress patterns observed in patient-specific cases, demonstrating the capabilities of the designed models. Conclusions: The collected statistical data on the aorta and the two idealized aorta models, covering prevalent arch variants known as Normal and Bovine types, are shown to be useful for examining the hemodynamics of the aorta. They also hold promise for applications in designing medical devices where anatomical statistics are needed.

    Keywords: Aorta, Idealized model, CAD model, In-vitro, In-silico, PIV, CFD

    Received: 20 Dec 2023; Accepted: 25 Jun 2024.

    Copyright: © 2024 Mansouri, Kemerli, Maciver and Amili. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Omid Amili, University of Toledo, Toledo, 43606, Ohio, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.