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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1353736
This article is part of the Research Topic Optical Coherence Tomography in Coronary Angiography View all articles

Comparative Study of Myocardial Perfusion and Coronary Flow Velocity Reserve Derived from Adenosine Triphosphate Stress Myocardial Contrast Echocardiography in Coronary Lesions with No/Mild Stenosis

Provisionally accepted
Xuebing Liu Xuebing Liu Chunmei Li Chunmei Li Qingfeng Zhang Qingfeng Zhang Qingguo Meng Qingguo Meng Hongmei Zhang Hongmei Zhang Zhaohuan Li Zhaohuan Li *
  • University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Background: Qualitative myocardial perfusion (QMP) derived from myocardial contrast echocardiography reflects the capillary flow, while coronary flow velocity reserve from Doppler spectrum (D-CFVR) of the left anterior descending coronary artery (LAD) is used to assess coronary microvascular function, particularly after excluding severe epicardial coronary stenosis. The present study aimed to assess the relationship of QMP and D-CFVR in detecting coronary microvascular disease (CMVD) by using adenosine triphosphate stress myocardial contrast echocardiography (ATP stress MCE). Methods and Results: Seventytwo patients (mean age: 54.22 ± 12.78 years) with chest pain and <50% coronary stenosis diagnosed by quantitative coronary angiography or dual-source CT underwent ATP stress MCE. The distribution of myocardial perfusion and CFVR value was estimated by experienced physicians. Of the 72 LAD with 0-50% diameter stenosis, 15 (21%) exhibited abnormal CFVR and 31 (43%) displayed abnormal perfusion with ATP stress MCE. Eleven of the 15 LAD territories (73%) with abnormal CFVR values showed abnormal perfusion. However, CFVR was considered normal in 20 LAD territories (35%), despite the presence of perfusion defect in the territory. Conclusion: Abnormal myocardial perfusion during ATP stress MCE was found in a sizable percentage of patients in whom CFVR of the supplying vessel was considered normal.

    Keywords: adenosine triphosphate stress, Myocardial contrast echocardiography, Myocardial perfusion, Coronary flow velocity reserve, Coronary microvascular disease

    Received: 11 Dec 2023; Accepted: 11 Sep 2024.

    Copyright: © 2024 Liu, Li, Zhang, Meng, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhaohuan Li, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China

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