AUTHOR=Ren Lingyun , Liu Wei , Chen Shanshan , Zeng Haibo 

TITLE=Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1341918

DOI=10.3389/fcvm.2024.1341918

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>Our recently published study discovers that exosomal microRNA (miR)-186-5p promotes vascular smooth muscle cell viability and invasion to facilitate atherosclerosis. This research aimed to explore the prognostic implication of serum exosomal miR-186-5p in acute myocardial infarction (AMI) patients receiving percutaneous coronary intervention (PCI).</p></sec><sec><title>Methods</title><p>One hundred and fifty AMI patients receiving PCI and 50 healthy controls (HCs) were screened. Serum exosomal miR-186-5p was detected by reverse transcriptase-quantitative polymerase chain reaction assay in AMI patients at admission and after PCI, as well as in HCs after enrollment. Major adverse cardiac events (MACE) were recorded during follow-up in AMI patients receiving PCI.</p></sec><sec><title>Results</title><p>Serum exosomal miR-186-5p was raised in AMI patients vs. HCs (<italic>P </italic>&lt; 0.001). Besides, serum exosomal miR-186-5p was positively linked to body mass index (<italic>P </italic>= 0.048), serum creatinine (<italic>P </italic>= 0.021), total cholesterol (<italic>P </italic>= 0.029), and C-reactive protein (<italic>P </italic>= 0.018); while it was reversely linked with estimated glomerular filtration rate (<italic>P </italic>= 0.023) in AMI patients. Interestingly, serum exosomal miR-186-5p was correlated with the diagnosis of ST-segment elevation myocardial infarction (<italic>P </italic>= 0.034). Notably, serum exosomal miR-186-5p was decreased after PCI vs. at admission (<italic>P </italic>&lt; 0.001). The 6-, 12-, 18-, and 24-month accumulating MACE rates were 4.5%, 8.9%, 14.8%, and 14.8% in AMI patients. Furthermore, serum exosomal miR-186-5p ≥3.39 (maximum value in HCs) after PCI (<italic>P </italic>= 0.021) and its decrement percentage &lt;median (35%) decrement (<italic>P </italic>= 0.044) estimated elevated MACE in AMI patients.</p></sec><sec><title>Conclusion</title><p>Serum exosomal miR-186-5p is reduced after PCI, and its post-PCI high level or minor decrease estimates increased MACE risk in AMI patients.</p></sec>