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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1337243
This article is part of the Research Topic Emerging Molecules in Pulmonary Hypertension: Diagnosis, Risk Prediction, Treatment and Prognosis View all articles
A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease
Provisionally accepted- 1 The First Affiliated Hospital of Anhui Medical University, hefei, China
- 2 First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China
Background: Pulmonary hypertension (PH) in patients with end-stage renal disease (ESRD) has a high incidence rate and mortality and its early identification is critical. However, whether a combination of clinical, electrocardiographic, and echocardiographic parameters can predict the occurrence of PH in patients with ESRD remains to be elucidated. Herein, we evaluated the predictive value of the combined score of these parameters. Methods: Data from 370 patients with newly diagnosed ESRD who underwent routine echocardiography and electrocardiography between May 2016 and May 2017 were retrospectively evaluated. The incidence of PH during a 60-month follow-up period was investigated. Twenty-one patients were excluded due to incomplete data among other reasons. Finally, 349 patients were included in the analysis, of whom, 158 (45%) developed PH. Results: Analysis of electrocardiogram reports suggested that a corrected Q-T interval (QTc) of >438.5 ms was associated with PH. Echocardiographic reports suggest that left atrial diameter (LAD), interventricular septum thickness in end-diastole (IVSd), stroke volume (SV), and pericardial effusion are also associated with PH development. Results of multivariate Cox analysis showed that LAD >3.785 cm, IVSd >1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion were independent predictors of PH in patients with ESRD. The incidence of new-onset PH increased significantly with increasing composite scores, that is, the sum of risk scores determined using hazard ratios. Conclusions: A total score that includes a combination of parameters such as LAD >3.785 cm, IVSd>1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion can help describe the risk of new-onset PH.
Keywords: Electrocardiography, Echocardiography, Pericardial Effusion, pulmonary hypertension, end-stage renal disease
Received: 12 Nov 2023; Accepted: 10 Oct 2024.
Copyright: © 2024 Ding, zhang, zhong, pan, chen, zhang, Wang, liao and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
fei zhang, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
jinbiao zhong, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
jiashan pan, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
yiding chen, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
ji zhang, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
guiyi liao, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
Zongyao Hao, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China
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