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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Hypertension
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1335395

A Mendelian randomization study on the association between systemic inflammatory regulators and essential and secondary hypertension

Provisionally accepted
Xiang Ji Xiang Ji Jiao Ren Jiao Ren Feng Dong Feng Dong Wei Peng Wei Peng *
  • Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

The final, formatted version of the article will be published soon.

    Background: Inflammation is an important driver of hypertension with numerous components, and there is a paucity of research on the specific inflammatory factors that induce hypertension; therefore, we wanted to investigate the relationship between specific inflammatory factors and hypertension. Purpose: A two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between systemic inflammatory regulators and hypertension (primary or secondary types).Method: a large-scale, published genome-wide association study (GWAS) meta-analysis encompassing 41 cytokines (involved 8,293 Finnish participants from three independent population cohorts: the Cardiovascular Risk in Young Finns Study (YFS), FINRISK1997, and FINRISK2002.)were utilized, a variety of analyses including MR-Egger, weighted median, simple mode and weighted mode were used as sensitive analyses, to corroborate the causal relationship between inflammatory regulators and hypertension. Additionally, we used MR-Egger intercept test and Mendelian Randomization Pleiotropy RE Sidual Sum and Outlier (MR-PRESSO global test) to further evaluate the presence of horizontal pleiotropy. Results：3 inflammatory regulators were found related to secondary hypertension, TNFb was negatively associated with risk of secondary hypertension, with a OR of one SD increase in genetically predicted TNFb causing 16.6% (95% CI: 4.4%-27.1%) lower risk of secondary hypertension.Similar trend was also found in MIP1b (OR=0.91; 95% CI 0.84-0.99, p = 0.024) and MIG (OR=0.88; 95% CI 0.78-0.99, p = 0.040). Additionally, there was not any evidence of 41 inflammatory regulators associated with primary hypertension. Conclusion: This study supports a negative correlation between TNFb, MIP1b, MIG and secondary hypertension.

    Keywords: Hypertension, Inflammation, Mendelian randomization, TNFB, MIP1b

    Received: 08 Nov 2023; Accepted: 26 Sep 2024.

    Copyright: © 2024 Ji, Ren, Dong and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Peng, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.