AUTHOR=Musigk Nicolas , Suwalski Phillip , Golpour Ainoosh , Fairweather DeLisa , Klingel Karin , Martin Pilar , Frustaci Andrea , Cooper Leslie T. , Lüscher Thomas F. , Landmesser Ulf , Heidecker Bettina 

TITLE=The inflammatory spectrum of cardiomyopathies

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1251780

DOI=10.3389/fcvm.2024.1251780

ISSN=2297-055X

ABSTRACT=<p>Infiltration of the myocardium with various cell types, cytokines and chemokines plays a crucial role in the pathogenesis of cardiomyopathies including inflammatory cardiomyopathies and myocarditis. A more comprehensive understanding of the precise immune mechanisms involved in acute and chronic myocarditis is essential to develop novel therapeutic approaches. This review offers a comprehensive overview of the current knowledge of the immune landscape in cardiomyopathies based on etiology. It identifies gaps in our knowledge about cardiac inflammation and emphasizes the need for new translational approaches to improve our understanding thus enabling development of novel early detection methods and more effective treatments.</p>