AUTHOR=Zheng Zilong , Tu Xiaokang , Jiang Chuanhao , Liu Feng , Fan Chengming 

TITLE=First case report of Candida guilliermondii native left-sided valve endocarditis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1273255

DOI=10.3389/fcvm.2023.1273255

ISSN=2297-055X

ABSTRACT=<p>Endocarditis, a life-threatening inflammation of the endocardium, is incited by bacteria, fungi, or other pathogenic microorganisms. Fungal endocarditis closely mirrors bacterial endocarditis in clinical signs and symptoms, leading to potential misdiagnoses. Here, we unveil the inaugural confirmed instance of native left-sided valve endocarditis attributed to <italic>Candida guilliermondii</italic>. Diagnosis was substantiated through valvular biopsies, blood and vegetative cultures. Treatment encompassed surgical excision of vegetations along with a six-week regimen of fluconazole administration (12 mg/kg/day), followed by 4 years of meticulous monitoring, resulting in sustained patient recovery.</p>