AUTHOR=Hu Tianyu , Qiu Qinghua , Xie Nianjin , Sun Mingming , Jia Qianjun , Huang Meiping 

TITLE=Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1247053

DOI=10.3389/fcvm.2023.1247053

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>The relationship between the optical flow ratio (OFR) and clinical outcomes in patients with coronary artery disease (CAD) after percutaneous coronary stent implantation (PCI) remains unknown.</p></sec><sec><title>Objective</title><p>To examine the correlation between post-PCI OFR and clinical outcomes in patients with CAD following PCI.</p></sec><sec><title>Methods</title><p>Patients who underwent optical coherence tomography (OCT) guided PCI at Guangdong Provincial People's Hospital were retrospectively and continuously enrolled. Clinical data, post-PCI OCT characteristics, and OFR measurements were collected and analyzed to identify predictors of target vessel failure (TVF) after PCI.</p></sec><sec><title>Results</title><p>Among 354 enrolled patients, 26 suffered TVF during a median follow-up of 484 (IQR: 400–774) days. Post-PCI OFR was significantly lower in the TVF group than in the non-TVF group (0.89 vs. 0.93; <italic>P</italic> = 0.001). In multivariable Cox regression analysis, post-PCI OFR (HR per 0.1 increase: 0.60; 95% CI: 0.41–0.89; <italic>P</italic> = 0.011), large stent edge dissection (HR: 3.85; 95% CI: 1.51–9.84; <italic>P</italic> = 0.005) and thin-cap fibroatheroma (TCFA) (HR: 2.95; 95% CI: 1.19–7.35; <italic>P</italic> = 0.020) in the non-stented segment were independently associated with TVF. In addition, the inclusion of post-PCI OFR to baseline characteristics and post-PCI OCT findings improved the predictive power of the model to distinguish subsequent TVF after PCI (0.838 vs. 0.796; <italic>P</italic> = 0.028).</p></sec><sec><title>Conclusion</title><p>The post-PCI OFR serves as an independent determinant of risk for TVF in individuals with CAD after PCI. The inclusion of post-PCI OFR assessments, alongside baseline characteristics and post-PCI OCT findings, substantially enhances the capacity to differentiate the subsequent manifestation of TVF in CAD patients following PCI.</p></sec>