AUTHOR=Hanuna Maja , Pattathu Joseph , Buech Joscha , Kamla Christine , Kneidinger Nikolaus , Behr Juergen , Milger Katrin , Veit Tobias , Nagel Marina , Abicht Jan , Dalla-Pozza Robert , Fischer Marcus , Jakob Andre , Hermann Matthias , Schramm Rene , Rosenthal Laura L. , Haas Nikolaus , Hörer Jürgen , Hagl Christian , Michel Sebastian G. TITLE=Case report: Central venous catheter thrombosis complicated by chronic thromboembolic disease/pulmonary hypertension in two children requiring parenteral nutrition JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1198204 DOI=10.3389/fcvm.2023.1198204 ISSN=2297-055X ABSTRACT=

Chronic thromboembolic pulmonary hypertension is a rare but life-threatening complication of long-term central venous catheters (CVC) in children. However, evidence in terms of potential treatment strategies and outcome data remains scarce. We describe two cases of CVC-related thrombosis (Hickman-catheter) complicated by recurrent pulmonary emboli. One patient experienced a complete thromboembolic obstruction of the right pulmonary artery with normal pulmonary pressures and the second patient suffered from a central thromboembolic obstruction of both pulmonary arteries associated with severe pulmonary hypertension. Both patients successfully underwent surgical thromboendarterectomy with deep hypothermic circulatory arrest.