AUTHOR=Cavalcante Pâmela Nogueira , Kanhouche Gabriel , Rosa Vitor Emer Egypto , Campos Carlos M. , Lopes Mariana Pezzute , Lopes Maria Antonieta Albanez A. de M. , Sampaio Roney Orismar , Brito Júnior Fábio Sândoli de , Tarasoutchi Flavio , Abizaid Alexandre Antonio Cunha 

TITLE=B-type natriuretic peptide and N-terminal Pro-B-type natriuretic peptide in severe aortic stenosis: a comprehensive literature review

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1182530

DOI=10.3389/fcvm.2023.1182530

ISSN=2297-055X

ABSTRACT=<p>B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers that are released in response to increased ventricular and atrial wall stress. Aortic stenosis (AS) leads to hemodynamic changes and left ventricular hypertrophy and may be associated with natriuretic peptide levels. Several studies have shown that increased natriuretic peptide levels are correlated with AS severity and can predict the need for intervention. It can be useful in risk stratification, monitoring follow-up, and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.</p>