AUTHOR=Correale Michele , Tricarico Lucia , Croella Francesca , Alfieri Simona , Fioretti Francesco , Brunetti Natale Daniele , Inciardi Riccardo M. , Nodari Savina 

TITLE=Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1157472

DOI=10.3389/fcvm.2023.1157472

ISSN=2297-055X

ABSTRACT=<p>Despite recent advances in chronic heart failure (HF) management, the prognosis of HF patients is poor. This highlights the need for researching new drugs targeting, beyond neurohumoral and hemodynamic modulation approach, such as cardiomyocyte metabolism, myocardial interstitium, intracellular regulation and NO-sGC pathway. In this review we report main novelties on new possible pharmacological targets for HF therapy, mainly on new drugs acting on cardiac metabolism, GCs-cGMP pathway, mitochondrial function and intracellular calcium dysregulation.</p>