AUTHOR=Valore Luca , Junker Till , Heilmann Eva , Zuern Christine S. , Streif Matthias , Drexler Beatrice , Arranto Christian , Halter Jörg P. , Berger Christoph T. 

TITLE=Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1135848

DOI=10.3389/fcvm.2023.1135848

ISSN=2297-055X

ABSTRACT=<sec><title>Introduction</title><p>Vaccine-induced myocarditis is a rare complication of messenger RNA (mRNA) COVID-19 vaccines.</p></sec><sec><title>Case presentation</title><p>We report a case of acute myopericarditis in a recipient of allogeneic hematopoietic cells following the first dose of the mRNA-1273 vaccine and the successful administration of a second and third dose while on prophylactic treatment with colchicine to successfully complete the vaccination.</p></sec><sec><title>Conclusion</title><p>Treatment and prevention of mRNA-vaccine-induced myopericarditis represent a clinical challenge. The use of colchicine is feasible and safe to potentially reduce the risk of this rare but severe complication and allows re-exposure to an mRNA vaccine.</p></sec>