AUTHOR=de la Torre Hernandez Jose M. , Veiga Fernandez Gabriela , Ben-Assa Eyal , Sainz Laso Fermin , Lee Dae-Hyun , Ruisanchez Villar Cristina , Lerena Piedad , Garcia Camarero Tamara , Cuesta Cosgaya Jose M. , Fradejas-Sastre Victor , Benito Mercedes , Barrera Sergio , Garcia-Unzueta Maria T. , Brown Jonathan , Gil Ongay Aritz , Zueco Javier , Vazquez de Prada Jose A. , Edelman Elazer R. TITLE=A new integrative approach to assess aortic stenosis burden and predict objective functional improvement after TAVR JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1118409 DOI=10.3389/fcvm.2023.1118409 ISSN=2297-055X ABSTRACT=Background

A non-negligible rate of patients undergoing transcatheter aortic valve replacement (TAVR) do not report symptomatic improvement or even die in the short-midterm. We sought to assess the degree of objective functional recovery after TAVR and its prognostic implications and to develop a predictive model.

Methods

In a cohort of patients undergoing TAVR, a prospective evaluation of clinical, anatomical, and physiological parameters was conducted before and after the procedure. These parameters were derived from echocardiography, non-invasive analysis of arterial pulse waves, and cardiac tomography. Objective functional improvement 6 months after TAVR was assessed using a 6-min walk test and nitro-terminal pro-brain natriuretic peptide (NT-proBNP) levels. The derived predictive model was prospectively validated in a different cohort. A clinical follow-up was conducted at 2 years.

Results

Among the 212 patients included, objective functional improvement was observed in 169 patients (80%) and subjective improvement in 187 (88%). Patients with objective functional improvement showed a much lower death rate at 2 years (9% vs. 31% p = 0.0002). Independent predictors of improvement were as follows: mean aortic gradient of ≥40 mmHg, augmentation index75 of ≥45%, the posterior wall thickness of ≤12 mm, and absence of atrial fibrillation. A simple integer-based point score was developed (GAPA score), which showed an area under the curve of 0.81 for the overall cohort and 0.78 for the low-gradient subgroup. In a validation cohort of 216 patients, these values were 0.75 and 0.76, respectively.

Conclusion

A total of 80% of patients experienced objective functional improvement after TAVR, showing a significantly lower 2-year mortality rate. A predictive score was built that showed a good discriminative performance in overall and low-gradient populations.