AUTHOR=Tian Kaijiang , Yang Yu , Zhou Kun , Deng Nianhua , Tian Zhen , Wu Zefan , Liu Xiyan , Zhang Fan , Jiang Zhisheng 

TITLE=The role of ROS-induced pyroptosis in CVD

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1116509

DOI=10.3389/fcvm.2023.1116509

ISSN=2297-055X

ABSTRACT=<p>Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF).</p>