AUTHOR=Tran Duy Cong , Le Linh Hoang Gia , Thai Truc Thanh , Hoang Sy Van , Do Minh Duc , Truong Binh Quang 

TITLE=Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1091612

DOI=10.3389/fcvm.2023.1091612

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>The severity of coronary artery disease is a prognostic factor for major adverse cardiovascular events in patients diagnosed with acute myocardial infarction. <italic>ACE</italic> I/D polymorphism is one of the genetic factors that may affect the severity of coronary artery disease. This study aimed to investigate the association between <italic>ACE</italic> I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction.</p></sec><sec><title>Materials and methods</title><p>A single-center, prospective, observational study was conducted at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam from January 2020 to June 2021. All participants diagnosed with acute myocardial infarction underwent contrast-enhanced coronary angiography. The severity of coronary artery disease was determined by Gensini score. <italic>ACE</italic> I/D genotypes were identified in all subjects by using the polymerase chain reaction method.</p></sec><sec><title>Results</title><p>A total of 522 patients diagnosed with first acute myocardial infarction were recruited. The patients' median Gensini score was 34.3. The II, ID, and DD genotype rates of <italic>ACE</italic> I/D polymorphism were 48.9%, 36.4%, and 14.7%, respectively. After adjusting for confounding factors, multivariable linear regression analysis showed that the <italic>ACE</italic> DD genotype was independently associated with a higher Gensini score compared with the II or ID genotypes.</p></sec><sec><title>Conclusion</title><p>The DD genotype of the <italic>ACE</italic> I/D polymorphism was associated with the severity of coronary artery disease in Vietnamese patients diagnosed with first acute myocardial infarction.</p></sec>