AUTHOR=Sun Zhiyu , Zhu Yongjie , Sun Xiaoyan , Lian Zhexun , Guo Mengqi , Lu Xiaohong , Song Ting , Feng Luxin , Zhang Yi , Xu Yawei , Ji Hongwei , Guo Junjie TITLE=Association of age at menarche with valvular heart disease: An analysis based on electronic health record (CREAT2109) JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1029456 DOI=10.3389/fcvm.2023.1029456 ISSN=2297-055X ABSTRACT=Background

The association between age at menarche and coronary heart disease has been reported, but the association between age at menarche and valvular heart disease (VHD) has not been described. We aimed to examine the association between age at menarche and VHD.

Methods

By collecting data from four medical centers of the Affiliated Hospital of Qingdao University (QUAH) from January 1, 2016, to December 31, 2020, we sampled 105,707 inpatients. The main outcome of this study was newly diagnosed VHD, which was diagnosed based on ICD-10 coding, and the exposure factor was age at menarche, which was accessed through the electronic health records. We used logistic regression model to investigate the association between age at menarche and VHD.

Results

In this sample (mean age 55.31 ± 13.63 years), the mean age at menarche was 15. Compared with women with age at menarche 14–15 years, the odds ratio of VHD in women with age at menarche ≤13, 16–17, and ≥18 years was 0.68 (95% CI 0.57–0.81), 1.22 (95% CI 1.08–1.38), and 1.31 (95% CI 1.13–1.52), respectively (P for all < 0.001). By restricting cubic splines, we found that later menarche was associated with increased odds of VHD (P < 0.001). Furthermore, in subgroup analysis of different etiologies, the similar trend persisted for non-rheumatic VHD.

Conclusions

In this large inpatient sample, later menarche was associated with higher risk of VHD.