AUTHOR=Chen Riken , Liao Huizhao , Deng Zhenan , He Zhenfeng , Zheng Zhenzhen , Lu Jianmin , Jiang Mei , Wu Xiaofeng , Guo Wenliang , Huang Zijie , Chen Huimin , Hong Cheng , Zhong Nanshan TITLE=Efficacy of computed tomography in diagnosing pulmonary hypertension: A systematic review and meta-analysis JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.966257 DOI=10.3389/fcvm.2022.966257 ISSN=2297-055X ABSTRACT=Objective

This study seeks to evaluate the diagnostic value of computed tomography (CT) in pulmonary hypertension.

Method

PubMed, Embase, Scopus, and Web of Science databases were searched to obtain the relevant English literature, and the retrieval time until June 2022. The quality of the included studies is evaluated using the QUADAS-2 tool. The quality of the included studies was assessed, followed by a meta-analysis, analyze heterogeneity, summarize sensitivity and specificity, draw the comprehensive subject working characteristics (sROC) curve, calculate the area under the curve and conduct subgroup analysis and sensitivity analysis to find the source of the heterogeneity.

Results

A total of 12 articles were included, all with pulmonary artery diameter/liter aortic diameter >1 or 1 as the diagnostic criteria for pulmonary hypertension, and a total of 1,959 patients were included. Deek’s funnel plot analysis suggests that there is no significant publication bias (P = 0.102). The combined sensitivity was 0.652 (95% CI: 0.579, 0.719), combined specificity was 0.830 (95% CI: 0.796, 0.880), positive likelihood ratio was 3.837 (95% CI: 3.215, 4.579), negative likelihood ratio was 0.419 (95% CI: 0.346, 0.507), diagnostic odds ratio was 9.157 (95% CI: 6.748, 12.427) and area under the summary receiver operating characteristic (SROC) curve was 0.84 (95% CI: 0.81, 0.87).

Conclusion

The CT examination of pulmonary artery diameter/aortic artery hypertension is worthy of clinical application.