AUTHOR=Ji Wenjun , Gao Lan , Sun Pengfei , Jia Jia , Li Jianping , Wang Xingang , Fan Fangfang , Zhang Yan 

TITLE=Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.948402

DOI=10.3389/fcvm.2022.948402

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>We aimed to explore the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance (IR), and vascular target organ damage (TOD) in a Beijing community-based population, China.</p></sec><sec><title>Methods</title><p>A total of 6,015 participants from an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, China were included in our analysis. Vascular TOD, such as carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), and the urine albumin-to-creatinine ratio (UACR) were all evaluated.</p></sec><sec><title>Results</title><p>The overall mean age of all the participants was 62.35 years, 3,951 (65.69%) were female, and mean TyG index was 8.81. In univariable regression analyzes, an increased TyG index was associated with higher cfPWV, baPWV, lnUACR, and higher risk of cfPWV ≥ 10 m/s, baPWV ≥ 1,800 cm/s, and UACR ≥ 30 mg/g, respectively. Multivariable regression analyzes showed subjects with the TyG index in top tertile had a significant increase in cfPWV (β = 0.29 m/s; 95% confidence interval [95% <italic>CI</italic>] 0.19–0.40; <italic>p</italic><sub>fortrend</sub> &lt; 0.001), baPWV (β = 69.28 cm/s; 95% <italic>CI</italic> 50.97–87.59; <italic>p</italic><sub>fortrend</sub> &lt; 0.001), lnUACR (β = 0.23; 95% <italic>CI</italic> 0.13–0.34; <italic>p</italic><sub>fortrend</sub> &lt; 0.001), and had a higher risk of cfPWV ≥ 10 m/s (odds ratio [<italic>OR</italic>] = 1.47; 95% <italic>CI</italic> 1.17–1.85; <italic>p</italic><sub>fortrend</sub> &lt; 0.001), baPWV ≥ 1,800 cm/s (<italic>OR</italic> = 1.79; 95% <italic>CI</italic> 1.48–2.17; <italic>p</italic><sub>fortrend</sub> &lt; 0.001), and UACR ≥ 30 mg/g (<italic>OR</italic> = 1.71; 95% <italic>CI</italic> 1.30–2.24; <italic>p</italic><sub>fortrend</sub> &lt; 0.001) after fully adjusting for age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), self-reported coronary heart disease (CHD) and stroke, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. Consistent conclusions were obtained in the subgroups without hypoglycemic and lipid-lowering medications or aged younger than 65 years old.</p></sec><sec><title>Conclusions</title><p>The TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.</p></sec>