AUTHOR=Bi Xuanye , Song Yanyan , Yang Chengzhi , Song Yunhu , Zhao Shihua , Qiao Shubin , Zhang Jinying 

TITLE=Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.947975

DOI=10.3389/fcvm.2022.947975

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>This study aimed to explore the effect of sex on left atrial (LA) remodeling and its relationship with myocardial fibrosis in patients with hypertrophic obstructive cardiomyopathy (HOCM).</p></sec><sec><title>Methods and results</title><p>A total of 85 patients with HOCM were enrolled. Myocardial fibrosis was quantified by the collagen volume fraction (CVF) in myocardial samples. The early atrial peak of emptying rate (PER-E) was assessed by LA volume/time (V/t) curves derived from cardiac magnetic resonance (CMR) imaging analysis. The PER-E index was PER-E normalized by left ventricular (LV) filling volume. Patients with HOCM showed a lower PER-E index than healthy controls (<italic>P</italic> = 0.027). Compared with men, the PER-E (<italic>P</italic> &lt; 0.001) and the PER-E indexes (<italic>P</italic> = 0.012) in women were lower. In CVF-stratified subgroups, a sex difference in the PER-E index was eliminated (<italic>P</italic> &gt; 0.05). The CVF was correlated with the PER-E and PER-E indexes in both sexes (all <italic>P</italic>-values were &lt;0.05). In multivariate regression analysis, sex (<italic>P</italic> = 0.007) and CVF (<italic>P</italic> &lt; 0.001) were independently correlated with PER-E (all <italic>P</italic>-values were &lt;0.05).</p></sec><sec><title>Conclusion</title><p>Patients with HOCM presented LA reverse remodeling. Impaired LA function was more common in female patients with HOCM due to their susceptibility to myocardial fibrosis.</p></sec>