AUTHOR=Wang Heng , He Yi , Fan Jia-Li , Li Xu , Zhou Bing-Yuan , Jiang Ting-Bo , He Yong-Ming 

TITLE=The predictive value of CatLet© angiographic scoring system for long-term prognosis in patients with acute myocardial infarction presenting > 12 h after symptom onset

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.943229

DOI=10.3389/fcvm.2022.943229

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>We have recently developed the <bold><italic><underline>C</underline></italic></bold>oronary <bold><italic><underline>A</underline></italic></bold>rtery <bold><italic><underline>T</underline></italic></bold>ree description and <bold><italic><underline>L</underline></italic></bold>esion <bold><italic><underline>E</underline></italic></bold>valua<bold><italic><underline>T</underline></italic></bold>ion (CatLet©) angiographic scoring system, which is capable of accounting for the variability in coronary anatomy, and risk-stratifying patients with coronary artery disease. This study aimed to clarify whether the CatLet score had a predictive value for long-term prognosis in patients with acute myocardial infarction (AMI) presenting &gt; 12 h after symptom onset.</p></sec><sec><title>Materials and methods</title><p>The CatLet score was calculated for 1,018 consecutively enrolled AMI patients, who were divided into 3 groups according to the CatLet score tertiles. The primary endpoint was major adverse cardiac events (MACEs), defined as a composite of myocardial infarction, cardiac death, and ischemia-driven revascularization; secondary endpoints were all-cause death, cardiac death, myocardial infarction, and ischemia-driven revascularization.</p></sec><sec><title>Results</title><p>The CatLet score was capable of predicting long-term prognosis at a median 4.9-year follow-up alone or after adjustment for risk factors. Multivariable-adjusted hazard ratios (95% CI)/unit higher score were 1.06 (1.05–1.08) for MACEs, 1.05 (1.03–1.07) for all-cause death, 1.06 (1.04–1.09) for cardiac death, 1.06 (1.04–1.08) for myocardial infarction, and 1.06 (1.04–1.08) for revascularization. The univariate model showed good calibration (χ<sup>2</sup> = 8.25, <italic>P</italic> = 0.4091) and good discrimination (area under ROC curve = 0.7086) for MACEs.</p></sec><sec><title>Conclusion</title><p>The CatLet score is an independent predictor of long-term clinical outcomes of patients with AMI presenting &gt; 12 h after symptom onset (<ext-link ext-link-type="uri" xlink:href="http://www.chictr.org.cn" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.chictr.org.cn</ext-link>; Registry Number: ChiCTR2000033730).</p></sec>