AUTHOR=Hu Min , Zhang Xin , Hu Can , Teng Teng , Tang Qi-Zhu 

TITLE=A brief overview about the adipokine: Isthmin-1

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.939757

DOI=10.3389/fcvm.2022.939757

ISSN=2297-055X

ABSTRACT=<p>Isthmin-1 is a secreted protein with multiple capability; however, it truly attracts our attention since the definition as an adipokine in 2021, which exerts indispensable roles in various pathophysiological processes through the endocrine or autocrine manners. In this review, we summarize recent knowledge of isthmin-1, including its distribution, structure, receptor and potential function.</p>