AUTHOR=Yu Shuhong , Yu Shuai , Zhang Hang , Dai Qingyong , Huang Hao , Luo Yi , Guo Zhiliang , Xiao Guodong TITLE=Oxygen saturation before and after mechanical thrombectomy and functional outcome in patients with acute ischemic stroke JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.935189 DOI=10.3389/fcvm.2022.935189 ISSN=2297-055X ABSTRACT=Background and purpose

Currently, there is a lack of effective neuroprotective strategies to break the ceiling effect of mechanical thrombectomy (MT), and one of the most promising is normobaric oxygen treatment. However, the impact of pre- and post-MT oxygen saturation on clinical outcomes in patients with acute ischemic stroke (AIS) remains unclear. We aimed to determine the influence of preoperative and postoperative oxygen saturation on 3-month poor outcome in patients with AIS.

Methods

A total of 239 consecutive stroke patients with successful recanalization by MT between May 2017 and March 2021 were analyzed. Oxygen saturation was measured non-invasively by pulse oximetry at baseline and continually after MT. Regression analysis was used to assess the association of preoperative and postoperative oxygen saturation with a 3-month poor outcome (modified Rankin Scale score: 3–6).

Results

Decreased preoperative oxygen saturation level was associated with an increased risk of poor outcome (odds ratio, 0.85; 95% CI, 0.73–0.98; P = 0.0293). Postoperative oxygen saturation had the opposite effect on poor outcome (odds ratio, 1.60; 95% CI, 1.13–2.27; P = 0.0088).

Conclusion

Preoperative and postoperative oxygen saturation have different impacts on 3-month poor outcome in patients with AIS with successful recanalization by MT.