AUTHOR=Mini Nathalie , Schneider Martin B. E. , Asfour Boulos , Mikus Marian , Zartner Peter A. 

TITLE=Duct Stenting vs. Modified Blalock-Taussig Shunt: New Insights Learned From High-Risk Patients With Duct-Dependent Pulmonary Circulation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.933959

DOI=10.3389/fcvm.2022.933959

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>As no data were available on the comparison of outcomes between modified Blalock-Taussig shunts (MBTs) vs. duct-stenting (DS) in patients with pulmonary atresia (PA) and an increased ductal tortuosity and in patients with pulmonary atresia and intact septum (PA-IVS) with right ventricle-dependent coronary circulation (RVDCC), we aimed to perform a single-center retrospective evaluation.</p></sec><sec><title>Methods</title><p>Between 2010 and 2019, 127 patients with duct-dependent pulmonary circulation (DDPC) underwent either MBTs (without additional repairs) (<italic>n</italic> = 56) or DS (<italic>n</italic> = 71). The primary endpoint was defined as arriving at the next planned surgery (Glenn or biventricular repair) avoiding one of the following: (1) unplanned surgery or unplanned perforation of the pulmonary valve (PVP) with a stent, (2) procedure-related permanent complications, and (3) death. Two subgroups were considered: (1) patients who had a ductal curvature index (DCI) &gt;0.45 (<italic>n</italic> = 32) and (2) patients with PA-IVS and RVDCC (<italic>n</italic> = 13). Ductal curvature index (DCI) was measured in all the patients to assess the tortuosity of the ducts. Patients with DCI &gt;0.45 were considered as being in a high-risk group for the duct-stenting; a previous study showed that the patients with a DCI &lt; 0.45 had a better outcome when compared with those with a DCI&gt; 0.45.</p></sec><sec><title>Results</title><p>The primary outcome was achieved equally in the two groups (77.5% in DS, 75% in MBTs). Hospital deaths, need for ECMO, and the occurrence of major complications was more frequent in the group with MBTs with an Odds Ratio (OR) of 5, 0.8, and 4, respectively, and a 95% Confidence Interval (<italic>CI</italic>) 1.1–22.6, 0.7–0.9, and 1.6–10.3, respectively, and a <italic>P</italic>-value &lt; 0.05. For the two subgroups, the primary outcome was achieved in 64% of patients with a DCI &gt;0.45 who received MBTs compared to 20% in those with DS (OR 3.5, 95% <italic>CI</italic> 1.2–10, <italic>P</italic> 0.005). While 74.1% of the patients with PA-IVS and RVDCC after DS had achieved the primary outcome, all patients with MBTs had an impaired outcome (OR 3.5, 95%<italic>CI</italic> 1–11.2, <italic>P</italic> 0.004).</p></sec><sec><title>Conclusion</title><p>MBTs showed a better outcome in patients with tortuous ducts compared to DS. DS seems to be superior in patients with DDPC with DCI &lt;0.45 and patients with PA-IVS with RVDCC.</p></sec>