AUTHOR=Wu Yun-Yun , Shan Su-Kang , Lin Xiao , Xu Feng , Zhong Jia-Yu , Wu Feng , Duan Jia-Yue , Guo Bei , Li Fu-Xing-Zi , Wang Yi , Zheng Ming-Hui , Xu Qiu-Shuang , Lei Li-Min , Ou-Yang Wen-Lu , Tang Ke-Xin , Li Chang-Chun , Ullah Muhammad Hasnain Ehsan , Yuan Ling-Qing TITLE=Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.912358 DOI=10.3389/fcvm.2022.912358 ISSN=2297-055X ABSTRACT=

Vascular calcification is prevalent in aging, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well-understood. It has been progressively recognized that vascular calcification depends on the bidirectional interactions between vascular cells and their microenvironment. Exosomes are an essential bridge to mediate crosstalk between cells and organisms, and thus they have attracted increased research attention in recent years. Accumulating evidence has indicated that exosomes play an important role in cardiovascular disease, especially in vascular calcification. In this review, we introduce vascular biology and focus on the crosstalk between the different vessel layers and how their interplay controls the process of vascular calcification.