AUTHOR=Guo Yuting , Zhang Wei , Zhou Xinger , Zhao Shihao , Wang Jian , Guo Yi , Liao Yichao , Lu Haihui , Liu Jie , Cai Yanbin , Wu Jiao , Shen Mingzhi TITLE=Roles of Ferroptosis in Cardiovascular Diseases JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.911564 DOI=10.3389/fcvm.2022.911564 ISSN=2297-055X ABSTRACT=

Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation between ferroptosis and various cardiovascular diseases such as atherosclerosis, acute myocardial infarction, ischemia/reperfusion injury, cardiomyopathy, and heart failure. Herein, we will review the contributions of ferroptosis to multiple cardiovascular diseases and the related targets. Further, we discuss the potential ferroptosis-targeting strategies for treating different cardiovascular diseases.